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首页> 外文期刊>Bone marrow transplantation >CMV pneumonia in allogeneic BMT recipients undergoing early treatment of pre-emptive ganciclovir therapy.
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CMV pneumonia in allogeneic BMT recipients undergoing early treatment of pre-emptive ganciclovir therapy.

机译：接受先予更昔洛韦治疗的同种异体BMT接受者的CMV肺炎。

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摘要

The incidence, treatment and outcome of CMV interstitial pneumonia (CMV-IP) were reviewed in 139 consecutive allogeneic BMT patients undergoing extended CMV antigenemia surveillance and two different ganciclovir (GCV) strategies to control CMV infection. Nineteen cases of CMV-IP were reviewed, 16 of 63 patients (25.4%) who received early GCV treatment (ET) and three of 76 patients (3.9%) who received preemptive (PE) GCV therapy. In the ET group, the median time for occurrence of CMV-IP was 55 (range 36 to 311) days. Two patients had three episodes of CMV-IP recurrences after day +100. CMV-IP-related death occurred in two patients (15.4%). In the PE group, 41 patients received pre-emptive GCV therapy prompted by the appearance of positive antigenemia > or =2 cells. The median time for the occurrence of CMV-IP was 92 (range 48 to 197) days. Response to therapy was observed when GCV was introduced within 6 days of antigenemia positivity. The use of IVIg in association with GCV did not play a major role in response to therapy. The median time for occurrence of CMV-IP was delayed during PE strategy and the cost-effectiveness of CMV surveillance after day +100 should be investigated in this population.
机译：回顾了139名连续的异基因BMT患者的CMV间质性肺炎（CMV-IP）的发生，治疗和结局，这些患者均接受了扩展的CMV抗原血症监测和两种更昔洛韦（GCV）策略来控制CMV感染。回顾了19例CMV-IP，其中63例患者中有16例（25.4％）接受了早期GCV治疗（ET），76例患者中有3例（3.9％）接受了抢先（PE）GCV治疗。在ET组中，CMV-IP发生的中位时间为55天（36到311）。在+100天后，两名患者发生了3次CMV-IP复发。两名患者（15.4％）发生了CMV-IP相关的死亡。在PE组中，有41名患者因出现阳性抗原血症>或= 2细胞而接受了抢先式GCV治疗。发生CMV-IP的中位时间为92天（48至197）。当在抗原血症阳性的6天内引入GCV时，观察到对治疗的反应。 IVIg与GCV联合使用在治疗反应中没有发挥主要作用。在PE策略中，CMV-IP发生的中位时间被延迟，在该人群中+100天后进行CMV监测的成本效益应进行调查。

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