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首页> 外文期刊>Genetic testing and molecular biomarkers >Genotypic Analyses of the Sclerostin rs851056 and Dickkopf rs1569198 Polymorphisms in Mexican-Mestizo Postmenopausal Osteoporosis: A Case-Control Study
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Genotypic Analyses of the Sclerostin rs851056 and Dickkopf rs1569198 Polymorphisms in Mexican-Mestizo Postmenopausal Osteoporosis: A Case-Control Study

机译:基因型分析Sclerostin rs851056和Dickkopf rs1569198多态性在Mexican-Mestizo绝经后骨质疏松症:一个病例对照研究

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摘要

Background: The Wnt/beta catenin pathway promotes bone mineralization stimulating proliferation, differentiation, and survival of osteoblasts; it also inhibits osteoclast differentiation and osteocyte activity. Sclerostin (SOST) and Dickkopf 1 (DKK1) are Wnt/beta catenin pathway inhibitors. Genetic variability in the expression of SOST and DKK1 might be involved in the development of postmenopausal osteoporosis (OP).
机译:背景:Wnt /β连环蛋白通路促进骨矿化刺激细胞增殖,成骨细胞的分化,和生存;还能抑制破骨细胞分化和骨细胞的活动。Dickkopf 1 (DKK1) Wnt /β连环蛋白通路抑制剂。苏斯特和DKK1可能参与绝经后骨质疏松症(OP)的发展。

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