In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma

Karamat Uzma; Ejaz Samina; Hameed Yasir

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In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma

机译：在Silico-Analysis Multi-Omics数据确定了共济失调毛细血管,突变基因作为一个乳腺浸润性的潜在生物标志物癌

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Background: The elevated global burden of the breast invasive carcinoma (BRIC) and lack of appropriate biomarkers for its early detection and treatment requires extensive investigation to enhance understanding regarding BRIC associated molecular alterations. Ataxia telangiectasia mutated (ATM) is a multifunctional tumor suppressor gene, which participates in the DNA damage response pathway and cellular checkpoint activation. Several studies have reported the reduction of ATM expression as a reliable biomarker of BRIC. However, its role as a clinicopathological feature-specific biomarker still needs to be explored.

机译：背景:升高的全球负担的乳腺浸润性癌(金砖四国)和缺乏适当的早期生物标志物的检测和治疗需要广泛的调查关于金砖四国有关增进了解分子的改变。突变(ATM)是一种多功能的肿瘤抑制基因,参与DNA损伤反应通路和细胞检查点激活。减少ATM表达式作为一个可靠的金砖四国的生物标志物。临床病理的feature-specific生物标志物仍然需要探索。

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《Genetic testing and molecular biomarkers》 |2021年第4期|263-275|共13页
作者
Karamat Uzma; Ejaz Samina; Hameed Yasir;
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作者单位

Islamia Univ Bahawalpur, Dept Biochem, Inst Biochem Biotechnol & Bioinformat, Bahawalpur 63100, Pakistan;

Islamia Univ Bahawalpur, Dept Biotechnol, Inst Biochem Biotechnol & Bioinformat, Bahawalpur, Pakistan;

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原文格式 PDF
正文语种英语
中图分类遗传学;
关键词
Tumor Suppressor Genes; Genes; invasive carcinomaBiological MarkersBreastAtaxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsBreast CancerDNA damage response;

机译：肿瘤抑制基因;基因;入侵carcinomaBiological MarkersBreastAtaxiaTelangiectasiaAtaxia毛细管扩张突变ProteinsBreast CancerDNA损伤反应;

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1. Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80 [J] . Mingming Xiao, Xuesong Li, Yang Su, 癌症生物学与医学：英文版 . 2020,第003期
2. Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80 [J] . Mingming Xiao, Bo Xu, Xuesong Li, 癌症生物学与医学（英文版） . 2020,第3期
3. A Correlative Study of Ataxia-telangiectasia Mutated Protein Expression of Four Tumor Cell Lines and Their Radiosensitivity after Different LET Radiation [J] . Wei Wei, Li Wenjian, Wang Zhuanzi, 近代物理研究所和兰州重离子加速器实验室年报：英文版 . 2008,第001期
4. Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers [J] . Savva Constantinos, De Souza Karen, Ali ReemRakha Emad A.Green Andrew R.Madhusudan Srinivasan Breast cancer research and treatment. . 2019,第1期

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In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma

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