GPR55 - a putative 'type 3' cannabinoid receptor in inflammation

Hyewon Yang; Juan Zhou; Christian Lehmann

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GPR55 - a putative 'type 3' cannabinoid receptor in inflammation

机译：GPR55——一个假定的“3型”大麻素受体在炎症

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G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classical cannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes a different signaling system and downstream cascade associated with the receptor. Therefore, GPR55 has emerged as a putative "type 3" cannabinoid receptor, establishing a novel class of cannabinoid receptor. Furthermore, the recent evidence of GPR55-CB1 and GPR55-CB2 heteromerlzation along with its broad distribution from central nervous system to peripheries suggests the importance of GPR55 in various cellular processes and pathologies and as a potential therapeutic target in inflammation.

机译：55 G protein-coupled受体(GPR55)股票大量的大麻素CB1和CB2配体与受体尽管低的同源性古典大麻素受体。GPR55尚未完全阐明;GPR55利用不同的信号系统下游梯级与受体有关。因此,GPR55已经成为公认的“类型大麻素受体3”,建立一部小说类的大麻素受体。最近的证据GPR55-CB1 GPR55-CB2heteromerlzation及其广泛分布在中枢神经系统外围表明GPR55的重要性各种细胞过程和病态一个潜在的治疗目标在炎症。

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《Journal of basic and clinical physiology and pharmacology》 |2016年第3期|297-302|共6页
作者
Hyewon Yang; Juan Zhou; Christian Lehmann;
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作者单位

Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, QE II;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
GPR55 gene; Receptors, Cannabinoid; InflammationImmunomodulationCNR2 gene;

机译：GPR55基因;Receptors,;

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GPR55 - a putative 'type 3' cannabinoid receptor in inflammation

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