Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels

Nahla S. El-Shenawy; Reham Z. Hamza

首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels

【24h】

Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels

机译：肾毒性的钠丙戊酸钠和保护半胱氨酸在生化和老鼠的角色组织学水平

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background: This study investigated whether the combination of sodium valproate (SV) with L-cysteine (LC) can decrease the SV toxicity of kidneys. SV caused alternation in oxidative/antioxidant balance. Methods: Biochemical estimations included the determination of oxidative stress markers like thiobarbituric acid-reactive substances in kidney tissue, and enzymatic antioxidant activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glu-tathione reductase as well as total antioxidant capacity were evaluated in renal tissues. Creatinine and uric acid levels in the serum were also determined to assess kidney function. Pathological examination of the kidney was also performed. Results: Increasing the levels of lipid peroxidation and decreasing the enzymatic activity (SOD, CAT, and GPx) as well as total antioxidant capacity of rats was shown with different doses of SV. Impairment in renal function tests suggests a decreased glomerular filtration rate, as serum creatinine was elevated. Histopathological changes of kidney tissue treated with SV reveal the proximal and the distal convoluted tubules that show hydropic changes (small white vacuoles within the cytoplasm and the glo-meruli show hypercellularity).

机译：背景:本研究调查是否结合丙戊酸钠钠(SV)半胱氨酸(LC)可以降低SV毒性肾脏。氧化和抗氧化的平衡。生化估计包括测定氧化应激标志物硫代巴比土acid-reactive物质在肾组织,酶促抗氧化等活动超氧化物歧化酶(SOD)、过氧化氢酶(CAT),谷胱甘肽过氧化物酶(GPx) glu-tathione还原酶和总抗氧化能力在肾组织评估。血清尿酸水平也确定评估肾脏功能。病理检查肾也执行。脂质过氧化,减少酶活动(SOD, CAT和GPx)以及总大鼠的抗氧化能力不同剂量的SV。功能测试表明降低肾小球滤过率、血清肌酐升高。组织处理SV揭示近端和远曲小管显示水肿的变化(白色的小液泡中细胞质和glo-meruli显示肾小球内)。

著录项

来源
《Journal of basic and clinical physiology and pharmacology》 |2016年第5期|497-504|共8页
作者
Nahla S. El-Shenawy; Reham Z. Hamza;
展开▼
作者单位

Faculty of Science, Zoology Department, Suez Canal University, Ismailia, 41522, Egypt;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类药学;
关键词
Kidney; Sodium Valproate; CysteineGlomerular Filtration Rate DecreasedNephrotoxicityhistopathologyLipid PeroxidationRatsSuperoxide DismutaseKidney Function TestRenal Tissuethiobarbituric acid-reactive substances;

机译：滤过率DecreasedNephrotoxicityhistopathologyLipidPeroxidationRatsSuperoxide DismutaseKidney函数TestRenal Tissuethiobarbituricacid-reactive物质;

相似文献

外文文献
中文文献

1. Protective effect of sodium valproate on motor neurons in the spinal cord following sciatic nerve injury in rats [J] . Fei Wu, Danmou Xing, Zhengren Peng, 中国神经再生研究（英文版） . 2006,第9期
2. Protective role of Triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats [J] . Udhaya Lavinya Baskaran, Sherry Joseph Martin, Rasool Mahaboobkhan, 结合医学学报：英文版 . 2015,第002期
3. Protective potency of Meristotropis xanthioides against nephrotoxicity in a rat model along with its antioxidant and antibacterial activities [J] . Roya Karamian, Mostafa Asadbegy, Siamak Yari 亚太热带医药杂志（英文版） . 2017,第10期
4. The possible protective role of N-acetyl cysteine on duodenal mucosa of high fat diet and orlistat treated adult male albino rats and the active role of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) (histological and biochemical study) [J] . El-Shal Laila Moustafa, Abd El-Star Alyaa A., Azmy Abeer M.Elnegris Heba M. Ultrastructural pathology . 2022,第3期

机译：The possible protective role of N-acetyl cysteine on duodenal mucosa of high fat diet and orlistat treated adult male albino rats and the active role of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) (histological and biochemical study)
5. The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study [J] . Shalaby Amany Mohamed, Aboregela Adel Mohamed, Alabiad Mohamed AliSadek Mona Tayssir Ultrastructural pathology . 2021,第3期

机译：The Effect of Induced Diabetes Mellitus on the Cerebellar Cortex of Adult Male Rat and the Possible Protective Role of Oxymatrine: A Histological, Immunohistochemical and Biochemical Study
6. The Protective Role of Poplar Propolis Against Alcohol-Induced Biochemical and Histological Changes in Liver and Testes Tissues of Rats [J] . Baydilli Numan, Akinsal Emre Can, Doganyigit ZuleyhaEkmekcioglu OguzSilici Sibel erciyes medical journal . 2020,第2期

机译：The Protective Role of Poplar Propolis Against Alcohol-Induced Biochemical and Histological Changes in Liver and Testes Tissues of Rats

Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels

摘要

著录项

相似文献

相关主题

期刊订阅