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Quantum dots and photodynamic therapy in COVID-19 treatment

机译:量子点和COVID-19光动力治疗治疗

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摘要

Viral diseases are regarded as a global burden. The eradication of viral diseases is always a challenging task in medical research due to the high infectivity and mutation capability of the virus. The ongoing COVID-19 pandemic is still not under control even after several months of the first reported case and global spread. In the pursuit of a promising strategy, carbon dots could be considered as potential nanostructure against this viral pandemic. Carbon dots are photoluminescent carbon nanoparticles, smaller than 10 nm in dimension with a very attractive photostable and biocompatible properties which can be surfaced modified or functionalized. These photoluminescent tiny particles have captured much attention owing to their functionalization property and biocompatibility. Photodynamic therapy (PDT) is a technique that is widely used in cancer treatment and against various microbes. In this technique, a light-induced photosensitizer generates reactive oxygen species (ROS), ultimately killing the target cells. Considering these facts, an attempt has been made to review the current literature on viral inactivation using PDT approach. Accordingly, the mechanism of PDT action has been discussed, along with an update on the use of various photosensitizers (PSs) and nanoparticles. The capsid proteins and nucleic acid (RNA) of SARS-CoV-2 can be a possible target for PDT.
机译:病毒性疾病被认为是一个全球负担。总是一个根除病毒疾病在医学研究由于具有挑战性的任务高传染性和突变的能力病毒。控制甚至几个月后首次报道情况和全球传播。追求一个有前途的战略,碳点可以被认为是潜在的纳米结构吗在这种病毒流行。发光碳纳米颗粒,小比10纳米尺寸非常有吸引力photostable和生物相容性的属性可以修改或功能化浮出水面。发光已抓获的微小粒子关注由于其功能化房地产和生物相容性。疗法(PDT)是一种被广泛使用的技术在癌症治疗和各种微生物。在这种技术中,光致光敏剂产生活性氧(ROS),最终杀死靶细胞。考虑到这些事实,企图回顾当前文献病毒使用PDT失活的方法。讨论PDT作用机制,以及有一个更新不同的使用敏化(PSs)和纳米颗粒。衣壳蛋白和核酸(RNA)PDT SARS-CoV-2可以是一个可能的目标。

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