Signal Transduction of a Novel WBP2 Oncogene

Tinghine Chu; Sock Hong Seah; Yoon Pin Lim

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Signal Transduction of a Novel WBP2 Oncogene

机译：信号转导的小说WBP2致癌基因

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WW-domain binding protein 2 (WBP2) was first discovered as a ligand of the WW-domain of Yes-associated Protein (YAP). A decade after its discovery, our laboratory implicated WBP2 in breast cancer development. Since then, WBP2 had also been shown to be involved in other types of cancer, such as glioma, liver and skin cancer. The oncogenic properties of WBP2 are mediated by several oncogenic signalling pathways, including EGFR, PI3K/Akt,ER, Wnt, and Hippo signalling pathways. Recently, WBP2 was demonstrated to play roles in diseases other than cancer, such as infertility and deafness. In the near future, we envisage a growing body of literature surrounding the role of WBP2 in more cancer types and signalling pathways.

机译：WW-domain结合蛋白2 (WBP2)是第一个发现WW-domain的配体Yes-associated蛋白质(笨蛋)。发现,我们实验室WBP2卷入乳腺癌的发展。还参与其他类型的癌症,如胶质瘤、肝脏和皮肤癌。WBP2的致癌特性是由一些致癌信号通路,包括表皮生长因子受体PI3K / Akt,呃,Wnt和河马的信号通路。角色在疾病以外的其他癌症,如不孕和耳聋。想象周围越来越多的文献WBP2更多的癌症类型和的作用信号通路。

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《Proceeding of the Singapore National Academy of Science》 |2020年第1期|3-14|共12页
作者
Tinghine Chu; Sock Hong Seah; Yoon Pin Lim;
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作者单位

Department of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore, Singapore 117545;

NUS Graduate School for Integrative Sciences and Engineering National University of Singapore,Singapore 117456;

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原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Oncogenes; Skin Neoplasms; InfertilityMetabolic PathwaysCancer of SkinWBP2 geneCanonical Wnt Signaling PathwayNoncanonical Wnt Signaling PathwaysignalsPrecision MedicineNotch and Wnt Signaling PathwayDeafness;

机译：致癌基因;皮肤肿瘤;InfertilityMetabolic的PathwaysCancer SkinWBP2 geneCanonical Wnt信号PathwayNoncanonical Wnt信号PathwaysignalsPrecision MedicineNotch和Wnt信号PathwayDeafness;

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2. Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage [J] . Haiyan Yin, Jianrui Wei, Rui Zhang, 中国神经再生研究：英文版 . 2011,第32期
3. Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage [J] . Haiyan Yin, Jianrui Wei, Rui Zhang, 中国神经再生研究（英文版） . 2011,第32期
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机译：Phosphorylation of E-box binding USF-1 by PI3K/AKT enhances its transcriptional activation of the WBP2 oncogene in breast cancer cells
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机译：Two GRAS proteins, SCARECROW-LIKE21 and PHYTOCHROME A SIGNAL TRANSDUCTION1, function cooperatively in phytochrome A signal transduction
7. SIGNAL GTi: implementing task preemption and time intervals in the synchronous data flow language SIGNAL [C] . Rutten, E., Martinez, Real-Time Systems, 1995. Proceedings., Seventh Euromicro Workshop on . 1995

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Signal Transduction of a Novel WBP2 Oncogene

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