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首页> 外文期刊>Annals of surgical oncology >Comparison of diagnostic accuracy of frozen section with imprint cytology for intraoperative examination of sentinel lymph node in early-stage endometrial cancer: Results of senti-endo study
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Comparison of diagnostic accuracy of frozen section with imprint cytology for intraoperative examination of sentinel lymph node in early-stage endometrial cancer: Results of senti-endo study

机译：冷冻切片和烙印细胞学诊断早期子宫内膜癌术中前哨淋巴结的诊断准确性比较：

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Background. In early-stage endometrial cancer, intraoperative examination of sentinel lymph nodes (SLNs) can predict nodal involvement and avoid a second surgical procedure. Our goal was to determine the diagnostic accuracy (DA) of intraoperative examination in diagnosing metastatic pelvic SLNs. Methods. This was a retrospective study, including 125 patients with early stage endometrial cancer. Results of intraoperative examination by frozen section (FS) or imprint cytology (IC) were compared with final histology (serial sectioning and immunohistochemistry (IHC)). The diagnostic value of intraoperative examination was calculated. Results. Of the 111 patients with SLNs detected (89 %), 87 (78.5 %) had an intraoperative examination (30 with FS and 57 with IC). Intraoperative examination detected SLN metastases in 9 of 16 patients with metastatic SLN at definitive histology (sensitivity = 56.3 %): macrometastasis in 8 and micrometastasis in 1. Seven false-negative cases were found (43.7 %; micrometastases in 6 and isolated tumor cells in 1). The DA of intraoperative examination was 92 % (95 % confidence interval (CI), 84-96.7). For FS and IC, DA was 97.3 % (95 % CI, 85.8- 99.9) and 88 % (95 % CI, 75.7-95.5), respectively. Conclusions. FS has better DA than IC for intraoperative examination of SLNs in endometrial cancer. The main limitation of both techniques is in detecting micrometastasis and isolated tumor cells.
机译：背景。在早期子宫内膜癌中，术中检查前哨淋巴结（SLN）可以预测淋巴结转移并避免再次手术。我们的目标是确定术中检查在诊断转移性骨盆SLNs中的诊断准确性（DA）。方法。这是一项回顾性研究，包括125例早期子宫内膜癌患者。将术中冰冻切片（FS）或印迹细胞学（IC）的检查结果与最终组织学（串行切片和免疫组织化学（IHC））进行比较。计算术中检查的诊断价值。结果。在111例被检测为SLN的患者中（占89％），有87例（占78.5％）接受了术中检查（其中FS患者30例，IC患者57例）。在确定的组织学检查中，术中检查发现16例转移性SLN患者中有9例发生了SLN转移（敏感性= 56.3％）：8例为大转移，1例为微转移。7例为假阴性（43.7％）; 6例为微转移，6例为分离的肿瘤细胞。 1）。术中检查的DA为92％（95％置信区间（CI），84-96.7）。对于FS和IC，DA分别为97.3％（95％CI，85.8-99.9）和88％（95％CI，75.7-95.5）。结论在子宫内膜癌的术中检查中，FS比IC具有更好的DA。两种技术的主要局限性在于检测微转移和分离的肿瘤细胞。

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