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首页> 外文期刊>The journal of applied laboratory medicine. >Beyond Titer: Expanding the Scope of Clinical Autoantibody Testing
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Beyond Titer: Expanding the Scope of Clinical Autoantibody Testing

机译：超越效价:扩大了临床的范围自身抗体检测

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摘要

Background: Autoantibodies that bind self-antigens are a hallmark of autoimmune diseases, but can also be present in healthy individuals. Clinical assays that detect and titer antigen-specific autoantibodies are an important component of the diagnosis and monitoring of autoimmune diseases. Autoantibodies may contribute to disease pathogenesis via effector functions that are dictated by both the antigen-binding site and constant domain. Content: In this review, we discuss features of antibodies, in addition to antigen-binding specificity, which determine effector function. These features include class, subclass, allotype, and glycosylation. We discuss emerging data indicating that analysis of these antibody features may be informative for diagnosis and monitoring of autoimmune diseases. We also consider methodologies to interrogate these features and consider how they could be implemented in the clinical laboratory. Summary: Future autoantibody assays may incorporate assessment of additional antibody features that contribute to autoimmune disease pathogenesis and provide added clinical value.
机译：背景:结合自体抗原的自身抗体是自身免疫性疾病的标志,但可以吗在健康的人也在场。化验,检测和效价抗原自身抗体是一个重要的组成部分自身免疫性疾病的诊断和监测。自身抗体可能导致疾病发病机理通过效应函数由antigen-binding网站和常数域。讨论抗体的特性,除了确定antigen-binding特异性效应功能。子类、球蛋白、糖基化。新兴的数据表明这些分析抗体特性可能会有用的自身免疫性疾病的诊断和监测。我们也认为方法询问这些特性并考虑他们如何可能在临床实验室中实现。未来的自身抗体检测可能合并评估额外的抗体特性导致自身免疫性疾病发病机理提供额外的临床价值。

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