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Autoantibody Testing in Idiopathic Inflammatory Myopathies

机译:在特发性炎症性自身抗体测试肌肉疾病

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Idiopathic inflammatory myopathies (IIM), generally referred to as myositis, are a heterogeneous group of diseases characterized by muscle inflammation and/or skin involvement, diverse extra-muscular manifestations, as well as variable risk for malignancy and response to treatment. The categorization of IIM has evolved over the years with recent interest in the use of autoantibodies to classify patients into unique phenotypic subsets (1-3). The presence of autoantibodies, collectively referred to as myositis-specific antibodies (MSAs) in combination with epidemiologic, clinical, biological, and pathologic data have been observed in many studies to be relevant in the stratification of patients into homogeneous subgroups (1, 3, 4). Thus, MSA are increasingly viewed as valuable tools for diagnosis, stratification, prognosis, and management.
机译:特发性炎性肌病(IIM),一般称为肌炎,是一种异质群体为特征的疾病肌肉皮肤炎症和/或参与,不同extra-muscular表现,以及变量恶性肿瘤的风险和应对治疗。多年来的使用与最近的兴趣自身抗体对患者进行分类成独一无二的表型子集(1 - 3)。自身抗体,统称为myositis-specific抗体(MSAs)结合流行病学、临床生理和病理数据观察到许多研究是相关的分层的病人到均匀子组(1、3、4)。因此,MSA越来越多被视为有价值的诊断工具,分层、预后和管理。

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