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首页> 外文期刊>The journal of applied laboratory medicine. >Association of Antiribosomal P Antibody with Neurological and Systemic Manifestations in Patients with Systemic Lupus Erythematosus in Southwestern Colombia
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Association of Antiribosomal P Antibody with Neurological and Systemic Manifestations in Patients with Systemic Lupus Erythematosus in Southwestern Colombia

机译：协会Antiribosomal P抗体神经和系统性表现系统性红斑狼疮患者哥伦比亚西南部

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Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by heterogeneous pathogenesis, various clinical manifestations, and a broad spectrum of autoantibodies which recognize different cellular components. This study examines the clinical significance and serological associations of serum antiribosomal P antibodies (anti-P) derived from SLE patients in a population from southwestern Colombia. Methods: We performed a cross-sectional study of 66 SLE patients. Serum antiribosomal P0 autoantibodies were detected by line immunoassay using the ANA-LIA MAXX kit and processed on the automated HumaBlot 44FA system (Human Diagnostics, Germany). Results: Of the 66 SLE patients included in the study, 17 patients (25.76%) showed anti-P positivity by line immunoassay (IA), 47 (71.21 %) were negative, and results from 2 patients were indeterminate. We did not find an association with neuropsychiatric SLE (NPSLE), renal, or hepatic disorders (P>0.05). Laboratory findings indicated that anti-P positivity was significantly associated to anti-Smith (P = 0.001), anti-Ro60/SSA (P = 0.046), and anti-dsDNA antibodies (P = 0.034), the latter being true only when performed using indirect immunofluorescence (IIF). Conclusion: The anti-P antibodies are not associated with clinical manifestations such as NPSLE, lupus nephritis, or hepatic involvement in the southwest Colombian SLE population. Moreover, we confirmed previously reported association between anti-P antibody, serum anti-dsDNA, and anti-Smith.
机译：背景:系统性红斑狼疮(SLE)一种自身免疫性疾病的特点异构的发病机理,各种临床表现和广泛的自身抗体的识别不同的细胞组件。意义和血清学协会血清抗体antiribosomal P (anti-P)系统性红斑狼疮患者的人口哥伦比亚西南部。66系统性红斑狼疮患者的横断面研究。antiribosomal P0自身抗体检测线使用ANA-LIA MAXX装备和免疫测定在自动HumaBlot 44 fa系统处理(人类的诊断,德国)。系统性红斑狼疮患者包括在这项研究中,17岁的病人(25.76%)显示anti-P积极性免疫测定(IA), 47(71.21%)呈阴性结果2例患者是不确定的。没有找到一个与神经精神系统性红斑狼疮(NPSLE)、肾脏或肝脏疾病(P > 0.05)。anti-P积极性显著相关anti-Smith (P = 0.001), anti-Ro60 / SSA (P =0.046), anti-dsDNA抗体(P = 0.034),后者真的只有当使用执行间接免疫荧光法(IIF)。anti-P抗体并不相关临床表现如NPSLE、红斑狼疮肾炎,或者肝参与哥伦比亚西南人口系统性红斑狼疮。确认之前报道之间的联系anti-P抗体、血清anti-dsDNA和anti-Smith。

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