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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Are they being used safely? A retrospective cross-sectional tertiary health care survey of selective serotonin reuptake inhibitors prescribing practice in Singapore.
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Are they being used safely? A retrospective cross-sectional tertiary health care survey of selective serotonin reuptake inhibitors prescribing practice in Singapore.

机译：他们被安全使用?横断面三级医疗的调查选择性5 -羟色胺再摄取抑制剂在新加坡开练习。

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OBJECTIVES: To determine the prescribing pattern of the SSRIs and to evaluate the safety of current utilization of SSRIs associated with concomitant psychotropic medications in Singapore. METHODS: The average prescribed daily dose (PDD) for each SSRI was calculated and compared with the defined daily dose (DDD). Pearson's chi(2) test, one-way analysis of covariance (ANCOVA) and multinomial logistic regression were performed to examine the impacts of variables such as age, gender, patient type and concomitant psychotropic medications on the utilization of SSRIs. Safety issues were discussed by examining the potential metabolic drug interactions between the SSRIs and concomitant psychotropic medications. RESULTS: The most frequently prescribed SSRI was fluoxetine and the PDDs were slightly more than the DDDs for all these SSRIs except fluvoxamine. The SSRIs were mainly prescribed to the patients who were younger, female and outpatients. Psychotropics were more likely concomitantly used with fluvoxamine, sertraline and paroxetine, relative to fluoxetine. CONCLUSION: The prescribing pattern of SSRIs in a tertiary health center in Singapore is generally consistent with the accepted practices, although some safety concerns in terms of metabolic drug interactions were raised. This study provides useful baseline information for further in-depth studies for SSRIs usage both locally and for international comparison. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：目的:确定处方模式SSRIs和评估的安全当前的SSRIs与利用伴随的精神药物在新加坡。为每个SSRI剂量(PDD)计算而定义的日剂量(DDD)。培生的气(2)测试,单向的分析协方差(ANCOVA)和多项物流回归进行检查的影响变量如年龄、性别、病人类型和伴随的精神药物利用选择性血清素再吸收抑制剂。讨论了通过检查潜在的代谢ssri类药物和药物相互作用伴随的精神药物。规定SSRI最频繁氟西汀和广泛性成长障碍略多所有这些的ddd ssri类药物氟伏沙明除外。规定的ssri类药物主要是病人那些年轻女性和门诊病人。精神更有可能与此同时使用与氟伏沙明、帕罗西汀和舍曲林相对于氟西汀。ssri类药物的处方模式三级健康在新加坡中心通常是一致的公认的做法,尽管一些安全担忧的代谢药物的相互作用被提出。为进一步深入研究信息同时在本地及国际ssri类药物的使用比较。有限公司

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