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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Effect of glucose on tobacco withdrawal symptoms in recent quitters using bupropion or nicotine replacement.
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Effect of glucose on tobacco withdrawal symptoms in recent quitters using bupropion or nicotine replacement.

机译：葡萄糖对烟草戒断症状的影响最近使用安非他酮或尼古丁戒烟更换。

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RATIONALE AND OBJECTIVES: Glucose has been shown to alleviate the desire to smoke in abstaining heavy smokers and to increase 1-month abstinence rates on its own as well as when combined with nicotine patches. It is not known whether a single dose of glucose can provide additional withdrawal relief in patients who have already abstained for a period of time, and whether it can assist patients using bupropion. METHODS: Seventy-five volunteers from a smoking cessation clinic who maintained 1 week of validated continuous abstinence were randomized to receive four 3 mg dextrose or placebo (sorbitol) tablets. There were 31 bupropion and 44 NRT users. Measures of desire to smoke and of five withdrawal symptoms were taken before taking the tablets, and then at 5 min intervals for 20 min. RESULTS: Despite low baseline ratings of withdrawal discomfort, glucose tablets significantly reduced irritability and hunger in bupropion users. Two other effects including reduction in composite withdrawal score approached but did not reach statistical significance. The effects emerged 10-15 min after taking the tablets. No glucose effect was detected in patients using NRT. CONCLUSIONS: A single dose of glucose taken after a week of sustained abstinence may reduce withdrawal discomfort in patients on bupropion. Further research is warranted in combining glucose and bupropion, and in opportunistic use of glucose tablets in tempting situations during a smoking cessation attempt.
机译：基本原理和目标:葡萄糖已被证明为了减轻在弃权抽烟的欲望重度吸烟者,增加月禁欲利率的结合时一样尼古丁贴片。单剂量的葡萄糖可以提供额外的减压的患者已经撤军弃权在一段时间内,无论是可以帮助病人使用安非他酮。七十五名志愿者从戒烟诊所保持1周的验证连续被随机分配接受禁欲四个葡萄糖3毫克或安慰剂(山梨糖醇)平板电脑。有31日安非他酮和44 NRT用户。烟和五个措施的欲望戒断症状之前拍摄的平板电脑,然后在5分钟间隔20分钟。结果:尽管低基线的评级撤军不适,葡萄糖平板电脑显著降低易怒和饥饿安非他酮的用户。减少复合撤军得分接近但没有达到统计的意义。平板电脑。检测到使用NRT的病人。单剂量的葡萄糖经过一个星期的持续的禁欲可能会减少撤军安非他酮不适的病人。研究在结合葡萄糖和保证安非他酮,在机会使用葡萄糖平板电脑在诱人的情况下在吸烟停止尝试。

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