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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Depot antipsychotic use in schizophrenia: an East Asian perspective.
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Depot antipsychotic use in schizophrenia: an East Asian perspective.

机译：得宝抗精神病药物用于精神分裂症:东方亚洲的视角。

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AIMS: Few studies have examined the use of depot antipsychotics in East Asian patients with schizophrenia. This study examined the prevalence of depot antipsychotic use and its clinical correlates. METHODS: Across six East Asian countries and territories, 2399 patients with schizophrenia were surveyed using a standardized protocol. RESULTS: Depot antipsychotic medications were prescribed in 15.3% (n=368) of the patients, being the most common in Singapore, followed by Taiwan, Japan and China. Being on depot antipsychotic drugs was significantly associated with male gender (particularly in Taiwan and Japan), delusions in Japan, aggression, higher daily CPZ equivalent dose and co-prescription of anticholinergic drugs but less likely with disorganized speech (particularly in China) and negative symptoms (particularly in Japan and Singapore). On multivariate analysis, the significant associated factors were treatment setting, younger age, longer duration of illness, aggression and the lack of use of an oral, atypical antipsychotic. CONCLUSION: There was a wide variation in the prevalence of depot antipsychotic prescription, suggesting that it may not be guided by any recognizable principles and is more likely determined by local traditions and prescription culture. There is a need to re-examine the risk-benefit profile of each patient before deciding on the initiation or continuation of depot antipsychotic medication.
机译：目的:很少有研究调查了仓库的使用抗精神病药物的患者在东亚精神分裂症。得宝的抗精神病药物及其临床使用关联。国家和地区的2399名患者使用标准化的精神分裂症患者进行调查协议。药物的15.3% (n = 368)在新加坡的病人,最常见的,其次是台湾、日本和中国。得宝抗精神病药物是显著的与男性性别(特别是有关台湾和日本),妄想在日本,侵略,每日CPZ等效剂量和高它抗胆碱能药物更少可能与紊乱(尤其是演讲和阴性症状(尤其是在中国)日本和新加坡)。相关的重要因素进行治疗设置,年轻的年龄,疾病持续时间更长,侵略和缺乏使用口服,非典型抗精神病药物。得宝的患病率差异很大抗精神病药物的处方,这表明它可能不会遵循任何可识别的原理和更有可能取决于当地的传统文化和处方。重新审视各自的风险概况患者在决定启动之前或得宝抗精神病药物的延续。

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