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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis.
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Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis.

机译：比较新的催眠药物的功效失眠的短期管理:系统回顾和荟萃分析。

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OBJECTIVES: To compare the clinical effectiveness of zaleplon, zolpidem or zopiclone (Z-drugs) with either benzodiazepines licensed and approved for use in the UK for the short-term management of insomnia (diazepam, loprazolam, lorazepam, lormetazepam, nitrazepam, temazepam) or with each other. METHODS: MEDLINE, EMBASE, PsycINFO, Science Citation Index/Web of Science were searched from 1966 to March 2003 and The Cochrane Library, reference lists of included studies and a number of psychopharmacology journals. Randomized controlled trials comparing either benzodiazepines with the Z-drugs or any two of the Z-drugs in patients with insomnia were included. Outcome measures included: sleep onset latency, total sleep duration, number of awakenings, quality of sleep, adverse events, tolerance, rebound insomnia and daytime alertness. RESULTS AND CONCLUSIONS: Twenty four eligible studies were identified with a total study population of 3909 (17 studies comparing a Z-drug with a benzodiazepine and 7 comparing a Z-drug). Insufficient or inappropriately reported data meant that meta-analysis was possible only for a small number of outcomes. There are few clear, consistent differences between the drugs. Some evidence suggests that zaleplon gives shorter sleep latency but shorter duration of sleep than zolpidem, reflecting the pharmacological profiles of the drugs.
机译：目的:比较的临床有效性zaleplon,唑吡坦或zopiclone (Z-drugs)苯二氮卓类授权和批准在英国的短期管理使用失眠(loprazolam安定,氯羟去甲安定,lormetazepam、硝基安定、羟基安定)或与每个其他。科学引文索引/ Web的科学从1966年到2003年3月,Cochrane搜查了一遍图书馆,列表,包括研究和参考精神药理学杂志。随机对照试验苯二氮卓类与Z-drugs或任何两个Z-drugs失眠患者包括在内。延迟,总睡眠时间,数量醒来,睡眠质量,不良事件,宽容,失眠和白天的反弹警觉性。合格的研究确定了总研究人口3909(17个研究比较Z-drug苯二氮和7比较Z-drug)。数据意味着荟萃分析是可能的少量的结果。明确、一致的药物之间的区别。一些证据表明zaleplon给睡眠潜伏期缩短,但持续时间短睡眠比唑吡坦,反映了药物的药理档案。

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