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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Effect of citalopram on ouabain-induced arrhythmia in isolated guinea-pig atria.
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Effect of citalopram on ouabain-induced arrhythmia in isolated guinea-pig atria.

机译：西酞普兰对ouabain-induced心律失常的影响在孤立的豚鼠心房。

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摘要

The effect of citalopram (CTP) a selective serotonin reuptake inhibitor agent was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. CTP (2-32 microg/ml) produced a dose-dependent decrease in the force of contractions (7-62%), and in the rate of contractions (11-72%). Pre-administration of the atria with CTP inhibited the ouabain-induced arrhythmia in isolated atria. Ouabain alone (1.2 microg/ml) produced arrhythmia at 4.5 min, and asystole at 20.7 min. Pretreatment with CTP (8 microg/ml) significantly increased the time of onset of arrhythmia to 9.5 min. In addition CTP prolonged the beating of atria (survival time) to more than 56 min, and inhibited the occurrence of asystole. These findings indicate that CTP produces direct cardiac action, probably due to the inhibition of cardiac Na(+) and Ca(2+) channels. Moreover our results suggest that CTP may reduce the membrane conductance through inhibition of ionic channels which decrease ouabain-induced arrhythmia.
机译：西酞普兰(CTP)选择性的影响5 -羟色胺再摄取抑制剂剂进行了研究在自发ouabain-induced心律失常击败孤立豚鼠心房。microg /毫升)产生剂量依赖性降低收缩的力量(7 - 62%),和宫缩率(11 - 72%)。与CTP抑制了心房ouabain-induced心律失常在孤立的心房。乌本苷产生心律失常(1.2 microg /毫升)在4.5分钟,心搏停止为20.7分钟。预处理与CTP显著(8 microg /毫升)心律失常发作的时间增加到9.5分钟。除了CTP长期殴打心房(生存时间)超过56分钟抑制心搏停止的发生。研究结果表明CTP生产直接心脏行动,可能由于抑制心脏钠(+)和Ca(2 +)通道。结果表明CTP可以减少膜通过抑制离子通道电导减少ouabain-induced心律失常。

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