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首页> 外文期刊>Journal of the American Animal Hospital Association >Seizures as a Consequence of Hyperviscosity Syndrome in Two Dogs Naturally Infected with Leishmania infantum
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Seizures as a Consequence of Hyperviscosity Syndrome in Two Dogs Naturally Infected with Leishmania infantum

机译：癫痫是超高粘度的结果在两个狗自然感染综合症

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摘要

Serum hyperviscosity syndrome (HVS) was documented in two dogs with canine leishmaniasis (CanL) and seizures as the major clinical complaint. In both cases, laboratory abnormalities included mild non-regenerative anemia, thrombocytopenia, hypoalbuminemia, hyperproteinemia with monoclonal gammopathy, and marked serum hyperviscosity. CanL was diagnosed using cytology in one case and indirect immunofluorescence assay and conventional polymerase chain reaction in the second. Specific therapy with meglumine antimoniate and allopurinol(c) led to short-term remission in both dogs and normalization of serum viscosity. Although dogs rarely develop HVS, it should be suspected if hyperproteinemia and monoclonal gammopathy are present. Since CanL manifests with a variety of clinical presentations, including seizures resulting from HVS-induced central nervous system hypoxia, it should also be considered as a differential diagnosis in animals with seizures as a primary presenting sign.
机译：血清超高粘度综合症(HVS)记录在与犬利什曼病(CanL)和两只狗癫痫发作的主要临床投诉。情况下,实验室异常包括温和非再生贫血、血小板减少、低白蛋白血症,hyperproteinemia单克隆丙种球蛋白病,血清超高粘度。一个案例中,使用细胞学诊断间接免疫荧光法测定,传统的聚合酶链反应第二。antimoniate和别嘌呤醇(c)导致短期缓解在狗和血清正常化粘度。如果hyperproteinemia和应怀疑单克隆丙种球蛋白病。与各种各样的临床表现报告,包括导致癫痫发作HVS-induced中枢神经系统缺氧,也应该被认为是一个微分诊断与癫痫作为主要的动物呈现的迹象。

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