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首页> 外文期刊>Journal of the American Animal Hospital Association >Canine Alopecia Secondary to Human Topical Hormone Replacement Therapy in Six Dogs
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Canine Alopecia Secondary to Human Topical Hormone Replacement Therapy in Six Dogs

机译：狗人类局部激素脱发二级替代疗法在六个狗

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摘要

Alopecia is a common presenting complaint in veterinary medicine and is known to occur secondary to numerous primary conditions. In this report, six unrelated dogs from three households were subsequently determined to have developed alopecia as a result of accidental transdermal exposure to their owners' topical hormone replacement therapy (THRT). All cases presented with alopecia ranging in duration from 2 mo to 2.5 yr. All dogs demonstrated alopecia affecting the ventral neck, thoracic and abdominal surfaces, proximal lateral extremities, and lateral trunk. At the time of initial presentation, five of six dogs were also noted to have physical exam findings suggestive of feminization. In all cases, serum total thyroxine was within normal reference range. Affected skin was biopsied in five dogs, and all samples demonstrated four similar histological characteristics: basal melanosis, epidermal and infundibular follicular hyperkeratosis, kenogen hair follicles, and small sebaceous glands. All dogs had elevated baseline estradiol levels, and four dogs had concurrent elevations of baseline progesterone. Average time to onset of clinical signs in those dogs was 5.5 mo after the owners started THRT. Following discontinuation of THRT by the owners, all dogs had complete resolution of their clinical signs by 5.5 mo.
机译：脱发是一种常见的主诉兽医和发生继发于众多的主要条件。报告,六个无关的狗从三个家庭随后决心开发了吗脱发由于偶然的皮肤暴露于主人的局部激素替代疗法(THRT)。脱发持续时间从2月不等2.5年。所有的狗都证明了脱发影响腹侧颈、胸和腹部表面、近端外侧四肢和横向的树干。演讲中,五个六只狗也注意到有体检的吗女性化。是在正常参考范围。检查在5只宠物狗,所有样品吗展示四个相似的组织学特点:基底黑变病、表皮和漏斗状毛囊角化过度,kenogen毛囊和皮脂腺。狗有基线雌二醇水平升高,四条狗有并发海拔的基线孕激素。在这些迹象狗是5.5帽后业主开始THRT。的主人,所有的狗都有完整的决议他们的临床体征5.5莫。

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