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首页> 外文期刊>Genetic testing and molecular biomarkers >Association of Foxp3 and TGF-beta 1 Polymorphisms with Pre-Eclampsia Risk in Chinese Women
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Association of Foxp3 and TGF-beta 1 Polymorphisms with Pre-Eclampsia Risk in Chinese Women

机译：Foxp3协会和鉴定及1多态性中国妇女与先兆子痫的风险

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Purpose: The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes that encode forkhead box p3 (Foxp3) (rs3761549 C>T, rs2280883T>C, rs2232365 A>G and rs3761548 C>A) and transforming growth factor (TGF)-beta 1 (rs11466359 C>T, rs11466345 A>G and rs1800469 T>C) are associated with pre-eclampsia (PE) risk in Chinese women. Materials and Methods: SNPs were identified by polymerase chain reaction and ligase detection reaction. Allelic variant and genotype frequencies for Foxp3 and TGF-beta 1 were compared between PE women (n = 203) and healthy pregnant (HP) controls (n = 243). Results: The TGF-beta 1 rs1800469 TT genotype was found more frequently in PE patients than in HP controls [CC vs. CT+TT: odds ratio (OR) = 1.71; 95% confidence interval (CI): 1.04-2.81; p = 0.033], indicating that the T allele of rs1800469 confers a risk for PE [OR = 1.46; 95% CI: 1.12-1.92; p = 0.006]. The Foxp3 rs2232365 A allele was associated with severe PE specifically [OR = 1.70; 95% CI: 1.12-2.58; p = 0.01], compared with mild PE. There were no haplotype associations with PE. Conclusions: These findings indicate that allelic variants of TGF-beta 1 rs1800469 T influence PE risk in Chinese women. Pregnant Han Chinese women carrying the rs1800469 TT genotype were at increased risk of PE.
机译：目的:本研究的目的是调查无论是单核苷酸多态性(SNPs)的基因编码forkhead盒p3(具体)rs3761548 C >)和转化生长因子(TGF)β1 (rs11466359 C > T, rs11466345 > G和rs1800469 T > C)与先兆子痫相关联中国妇女(PE)的风险。方法:单核苷酸多态性被聚合酶链确认反应和连接酶检测反应。Foxp3和变异和基因型频率及1 PE女人之间的比较(n =203)和健康的怀孕(HP)控制(n =243)。PE患者的基因型被发现更频繁比惠普控制(CC与CT + TT:优势比(或)= 1.71;1.04 - -2.81;等位基因的rs1800469授予体育(或=的风险rs2232365等位基因与严重体育专门(OR = 1.70;0.01),而温和的体育。单体型与体育协会。这些发现表明,等位变异及1 rs1800469 T PE风险影响中国女性。携带rs1800469 TT基因型在增加体育的风险。

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