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首页> 外文期刊>Genetic testing and molecular biomarkers >Downregulated Expression of Chromobox Homolog 7 in Hepatocellular Carcinoma
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Downregulated Expression of Chromobox Homolog 7 in Hepatocellular Carcinoma

机译：表达下调表达Chromobox同族体7肝细胞癌

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Background: As an essential member of the Polycomb group (PcG) proteins, chromobox homolog 7 (CBX7) is found deregulated in some human cancers, and is thought to be a contributing factor in carcinogenesis. However, the expression and role of CBX7 in hepatocellular carcinoma (HCC) is still not well identified. Materials and Methods: The levels of CBX7 protein was quantified in 75 paired HCC and adjacent nontumor tissues by immunohistochemistry and comparisons were made using McNemar's chi-square test. The Kaplan-Meier estimate was used for survival analysis. Results: We found that the expression of CBX7 in HCC tissues was significantly lower than that of adjacent nontumor tissues. In addition, decreased CBX7 expression levels were correlated with liver cirrhosis in HCC patients. Furthermore, the survival times of HCC patients who were CBX7-expression-negative were shorter than HCC patients who were CBX7-expression-positive. Conclusion: Our results show that downregulation of CBX7 is related to HCC progression and a poor prognosis in HCC patients.
机译：背景:Polycomb不可或缺的成员集团(PcG)蛋白质,chromobox同族体7 (CBX7)发现管制在一些人类癌症,被认为是一个因素吗致癌作用。CBX7在肝细胞癌(HCC)还不是很确定。CBX7蛋白质的水平在75年被量化成对的肝癌和相邻nontumor组织免疫组织化学和比较使用McNemar检验法卡方检验。估计是用于生存分析。我们发现CBX7在肝细胞癌的表达组织显著低于相邻nontumor组织。CBX7表达水平与肝脏有关肝硬化肝癌患者。肝癌患者的生存时间CBX7-expression-negative短于肝细胞癌患者CBX7-expression-positive。结论:我们的结果显示。差别,对这些CBX7与HCC进展和贫穷肝癌患者的预后。

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