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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology. >Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
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Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis

机译：香叶醇Nrf2变弱氧化应激激活在食源性实验动脉粥样硬化

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摘要

Background: Preclinical and clinical studies suggest the use of antioxidants as an effective measure to reduce the progression of oxidative-stress-related disorders. Nuclear factor E2-related factor 2 (Nrf2) is a key component to cellular redox homeostasis in the attenuation of oxidative-stress-associated pathological processes. The objective of the current study was to evaluate the role of geraniol (GOH) in preserving the plasma lipid status, endothelial function, antioxidant status, and inhibition of lipid per-oxidation (LPO) in hamsters fed an atherogenic diet (AD). Methods: Male Syrian hamsters were randomly grouped into four groups: group 1 was control animals; group 2 was animals fed GOH alone (100 mg/kg bw po); group 3 was animals fed AD (standard pellet diet+10% coconut oil+0.25% cholesterol+0.25% cholic acid); and group 4 was fed AD+GOH (100 mg/kg bw) for 12 weeks. At the end of the feeding period, the animals were sacrificed and the liver, heart, and aorta from each group were analyzed for antioxidants, LPO markers, and histological changes.
机译：背景:临床前和临床研究建议使用作为一个有效的抗氧化剂措施减少的发展oxidative-stress-related紊乱。因子E2-related因子2 (Nrf2)是一个关键细胞氧化还原内稳态的组件衰减的oxidative-stress-associated病理过程。目前的研究是评估的作用香叶醇(吴)保持血浆脂质状态,血管内皮功能、抗氧化状态和抑制脂质per-oxidation(法律流程外包)仓鼠喂一个患饮食(广告)。叙利亚仓鼠被随机分为男性四组:第1组是控制动物;独自动物美联储吴作栋(100毫克/公斤体重po);组3动物美联储广告(标准颗粒椰子油饮食+ 10% + 0.25% + 0.25%胆固醇胆酸);毫克/公斤体重)为12周。期间,动物被牺牲和从每组肝脏、心脏和主动脉分析抗氧化剂,提供法律服务外包的标记,并且组织学变化。

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