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首页> 外文期刊>Genetic testing and molecular biomarkers >Low Gonadotropin Dosage Reduces Aneuploidy in Human Preimplantation Embryos: First Clinical Study in a UAE Population
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Low Gonadotropin Dosage Reduces Aneuploidy in Human Preimplantation Embryos: First Clinical Study in a UAE Population

机译：低促性腺激素用量减少了非整倍性人类早期胚胎:首先临床在阿联酋人口

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Background: Retrospective analysis of embryo aneuploidy in patients undergoing in vitro fertilization (IVF) cycles. Aim: To evaluate factors that might affect the incidence of embryo aneuploidy during IVF cycles. Methods: Three hundred twelve IVF cases were included in the present study. Preimplantation genetic testing for aneuploidy (PGT-A) was performed for all the subjects involved in the study. Subject stratification was done based on maternal age, gonadotropin drug dosage, and IVF outcomes data. Maternal age 35 years were placed in the Young age group and age 35 years were placed in the Advanced Maternal Age. Similarly, IVF drug administered 200 International units (IU) was considered low dosage, and 200 IU were considered high dosage. Patients were stratified into four groupsgroup 1: age 35 years and administered 200 IU; group 2: age 35 years and administered 200 IU; group 3: age 35 years and administered 200 IU; and group 4: age 35 years and administered 200 IU. PGT-A results were attained using next-generation sequencing-based protocol. Embryo transfer strategy included transabdominal ultrasound-guided embryo transfer. Statistical significance was calculated with the use of chi-square test. Results: One thousand fifty blastocyst trophectoderm biopsies from 312 IVF cases were retrieved. The IVF outcome of a total of 105 normal cases resulted in 65.71% pregnancies. Stratifying for maternal age and IVF drug stimulation with PGT-A analyses we found the Euploid embryo percentages equal to 37.59% in Group 1; 16.18% in Group 2; 22.44% in Group 3; and 2.59% in Group 4. Similarly the aneuploid embryo (percentage)s were 62.40% for Group 1; 83.81% for Group 2; 77.55% for Group 3; and 87.40% for Group 4. Conclusion: This is the first clinical study reporting that gonadotropin dosage may act as a contributing factor in increasing aneuploidy incidences for the patients undergoing IVF cycles in the UAE population. This study shows that in all patien
机译：背景:胚胎的回顾性分析非整倍性的病人接受体外受精周期。因素,可能会影响胚胎的发病率在体外受精周期异倍性。几百十二试管婴儿的病例中本研究。非整倍性(PGT-A)进行的受试者参与这项研究。分层是基于母亲的年龄,促性腺激素药物剂量和体外受精结果数据。母亲的年龄& 35年被放置年轻的年龄组和放置在35岁先进的母亲的年龄。管理& 200国际单位(IU)认为低剂量,200 IU高剂量。groupsgroup 1:年龄& 35年,管理& 200国际单位;服用200国际单位;管理& 200国际单位;年,服用200 IU。获得使用下一代sequencing-based协议。结论:超声引导下胚胎移植。统计学意义是与计算使用卡方检验。从312年五十囊胚滋养外胚层活检体外受精例检索。共有105名正常情况下导致65.71%怀孕。与PGT-A分析我们发现药物刺激整倍体胚胎百分比等于37.59%组1;在4组和2.59%。胚胎组1(百分比)为62.40%;组2 83.81%;4组为87.40%。临床研究报道,促性腺激素用量可以作为一个因素在增加吗非整倍性患者的发生率体外受精周期在阿联酋人口。表明疼痛。病人就医时最多的主诉

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