Osilodrostat shows promise for Cushing's disease

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Osilodrostat shows promise for Cushing's disease

机译：Osilodrostat展示了库兴氏病的承诺

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Treatment with the oral 1113-hy-droxylase inhibitor osilodrostat effectively maintains a normalized mean urinary free cortisol (mUFC) in patients with Cushing's disease (CD) in a phase III trial presented at ENDO 2019. While pituitary surgery is the first-line treatment recommended for most patients with CD, it is not always effective for all patients. Some patients still face recurrence, which necessitates additional therapy.

机译：1113 - hy - droxylase口服治疗抑制剂osilodrostat有效地维护归一化平均尿皮质醇(mUFC)的自由患者库兴氏病(CD)的一个阶段临床试验在ENDO 2019。手术是一线治疗建议对于大多数患者CD,并不总是所有患者有效。面临复发,这需要额外的治疗。

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《MIMS Doctor.》 |2019年第5期|18-18|共1页
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PEARL TOH;
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原文格式 PDF
正文语种英语
中图分类医药、卫生;
关键词
Patients; Cortisol.free; Pituitary glandClinical Trials, Phase III as TopicCushing diseaseRelapse;

机译：患者;皮质醇.free;垂体临床试验;III期主题库欣病复发;

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专利

1. Bilateral inferior petrosal sinus sampling for the treatment of Cushing＇s disease--Data from 52 cases from one institute over an eight-year period [J] . Changyan Fan, Xiuhua Shi, Qingfang Sun, 中国神经再生研究：英文版 . 2011,第28期
2. Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Data from 52 cases from one institute over an eight-year period [J] . Changyan Fan, Xiaoying Li, Guang Ning, 中国神经再生研究（英文版） . 2011,第28期
3. Osilodrostat in Cushing's disease: The risk of delayed adrenal insufficiency should be carefully monitored [J] . Frederic Castinetti, Vincent Amodru, Thierry Brue Clinical Endocrinology . 2023,第4期

机译：Osilodrostat in Cushing's disease: The risk of delayed adrenal insufficiency should be carefully monitored
4. Long-term outcomes of osilodrostat in Cushing's disease: LINC 3 study extension [J] . Fleseriu Maria, Newell-Price John, Pivonello RosarioShimatsu AkiraAuchus Richard J.Scaroni CarlaBelaya ZhannaFeelders Richard A.Vila GreisaHoude GhislaineWalia RamaIzquierdo MiguelRoughton MichaelPedroncelli Alberto M.Biller Beverly M. K. European journal of endocrinology . 2022,第4期

机译：Long-term outcomes of osilodrostat in Cushing's disease: LINC 3 study extension
5. Osilodrostat oral tablets for adults with Cushing's disease [J] . Martino Marianna, Aboud Nairus, Lucchetti BeatriceSalvio GianmariaArnaldi Giorgio Expert review of endocrinology & metabolism . 2022,第3期

机译：Osilodrostat oral tablets for adults with Cushing's disease
6. DIAGNOSTIC TESTING FOR ADDISON'S CUSHING'S DISEASE [C] . Richard W. Nelson Annual Meeting of the American Animal Hospital Association . 2007

机译：Addison和Cushing的疾病的诊断测试
7. STUDIES ON BOTANICAL AND AGRONOMIC CHARACTERISTICS IN CUSH-CUSH (DIOSCOREA TRIFIDA L.F.). [D] . HENRY, VANN COURTENAY RYCE. 1967

机译：CUSH-CUSH（DIOSCOREA TRIFIDA L.F.）中植物和农艺特性的研究。
8. Osilodrostat Is an Effective and Well-Tolerated Treatment for Cushing’s Disease (CD): Results From a Phase III Study With an Upfront Randomized Double-Blind Placebo-Controlled Phase (LINC 4) [O] . Mônica Gadelha, Marie Bex, Richard A Feelders, 2021

机译：Osilodrostat是一种有效且耐受性耐受性的缓解疾病（CD）：由前期随机双盲安慰剂控制相（LINC 4）的研究结果。
9. Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease [O] . Fleseriu, Maria, Pivonello, Rosario, Young, Jacques, 2015

机译：Osilodrostat，一种有效的口服11β-羟化酶抑制剂：22周，前瞻性，Cushing病的II期研究
10. Public Health Assessment for Kerr-McGee Corporate Cushing Refinery Cushing, PayneCounty, Oklahoma, Region 6. CERCLIS No. OKD980620934 [R] . 1997

机译：Kerr-mcGee Corporate Cushing Refinery Cushing，payneCounty，Oklahoma，Region 6的公共卫生评估.CERCLIs No. OKD980620934

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Osilodrostat shows promise for Cushing's disease

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