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首页> 外文期刊>Archives of Environmental Contamination and Toxicology >Tissue distribution of polychlorinated biphenyls and organochlorine pesticides and potential toxicity to Alaskan northern fur seals assessed using PCBs congener specific mode of action schemes.
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Tissue distribution of polychlorinated biphenyls and organochlorine pesticides and potential toxicity to Alaskan northern fur seals assessed using PCBs congener specific mode of action schemes.

机译：多氯联苯和有机氯农药的组织分布以及对多氯联苯的同类作用模式评估对阿拉斯加北部海狗的潜在毒性。

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The fur seal (Callorhinus ursinus) population has decreased in their primary breeding grounds in the Bering Sea; contamination is among suspected causes. Our goal was to better understand the extent of contamination of seal tissues with certain organochlorine compounds by measuring the concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in fur seal tissues from St. Paul Island, to gain a better perspective of tissue congener distribution and to evaluate the observed PCB levels against toxicologically significant levels for modes of action. Concentrations of 145 PCB congeners (Sigma(145)PCBs) and 12 OCPs were measured with gas chromatography-ion trap mass spectrometry in 8 different tissues of 10 male northern fur seals. The mean concentrations of SigmaOCPs [in ng/g lipid weight (lw)] were 1180 in blubber, 985 in the heart, 1007 in the liver, 817 in the kidney, 941 in muscle, 660 in reproductive tissues, 204 in the brain, and 322 in the lung. The mean concentrations of Sigma(145)PCBs (in ng/g lw) were 823 in blubber, 777 in the liver, 732 in the heart, 646 in reproductive tissues, 638 in muscle, 587 in the kidney, 128 in the lung, and 74.3 in brain tissues. Concentrations of PCBs affecting the aryl hydrocarbon receptor expressed as total PCB toxic equivalents (SigmaPCB-TEQs) ranged from 0.3 to 545 pg/g lw for the various tissues. The major contributors to SigmaPCB-TEQs are CB-118 in muscle, brain, lung, kidney, and liver, CB-126 in blubber, and CB-118 and CB-126 equally in the heart and reproductive tissues. Concentrations of PCBs affecting Ca(2+) homeostatsis expressed as the neurotoxic equivalent (NEQ) showed SigmaPCB-NEQs ranged from 17.7 to 215 ng/g lw in all tissues. Although no composite measure of perturbation of thyroid function is available, sufficient amounts of congeners with high binding to the thyroxine transport system were present to warrant consideration of this mode of action in future studies. Analyses of 145 PCBs and mode of action evaluation suggest that PCB contamination could potentially exert an effect on the Alaskan northern fur seal population although the PCB concentrations have been decreasing in the fur seals over the last decade.
机译：在白令海的主要繁殖地，海狗（Callorhinus ursinus）的种群减少了;污染是可疑的原因之一。我们的目标是通过测量圣保罗岛毛皮海豹组织中的多氯联苯（PCB）和有机氯农药（OCP）的浓度，更好地了解海豹组织被某些有机氯化合物污染的程度，以便更好地了解组织同种异体的分布，并根据毒理学上的显着性水平评估观察到的多氯联苯水平的作用方式。用气相色谱-离子阱质谱法在10个北北方海豹的8个不同组织中测量了145种PCB同系物（Sigma（145）PCBs）和12种OCP的浓度。 SigmaOCP的平均浓度[以ng / g脂质重量（lw）为单位]为：脂肪1180，心脏985，肝脏1007，肾脏817，肌肉941，生殖组织660，大脑204，和322在肺部。 Sigma（145）PCBs的平均浓度（以ng / g lw计）分别为823脂，777脂，732素，646素，生殖组织，638脂，肾脏587脂，肺128脂。和74.3在脑组织中。对各种组织而言，影响芳基烃受体的PCBs的总PCB毒性当量（SigmaPCB-TEQs）浓度范围为0.3至545 pg / g lw。 SigmaPCB-TEQ的主要贡献者是肌肉，脑，肺，肾和肝脏中的CB-118，润滑脂中的CB-126，心脏和生殖组织中的CB-118和CB-126。多氯联苯影响Ca（2+）稳态的PCB浓度表示为神经毒性当量（NEQ），表明所有组织中SigmaPCB-NEQ的范围为17.7至215 ng / g lw。尽管尚无可综合测量甲状腺功能紊乱的方法，但仍存在足够数量的与甲状腺素转运系统具有高结合力的同类物，以保证在未来的研究中考虑这种作用方式。对145种多氯联苯的分析和作用方式评估表明，尽管近十年来海狗中多氯联苯的浓度一直在下降，但多氯联苯的污染可能会对阿拉斯加北部海狗的种群产生影响。

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