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A Circulating MicroRNA-375 for the Detection of Liver Cancer: A Meta-Analysis

机译：用于检测肝癌的循环 MicroRNA-375：荟萃分析

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Background: Liver cancer is one of the most frequently diagnosed malignant tumors, with an extremely high incidence rate. Diagnosis of liver cancer is difficult with the existing methods and improved biomarkers are urgently needed. A number of studies have established a link between abnormal miR-375 expression and liver cancer. Therefore, we conducted a systematic analysis to appraise whether miR-375 can be used as a screening tool for liver cancer detection.Methods: Through a systematic database search, studies investigating miR-375 expression in serum by the quantitative real-time reverse transcription-PCR (qRT-PCR) method were included in the study. A total of 1,100 participants (576 with liver cancer and 534 without liver cancer) were recruited. The efficacy of microRNA-375 in the detection of liver cancer was assessed by sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC).Results: The pooled sensitivity and specificity of miR-375 in the detection of liver cancer were 0.91 (95% confidence interval [CI]: 0.74-0.98) and 0.83 (95% CI: 0.67-0.92), respectively. Furthermore, the pooled PLR was 5.40 (95% CI: 2.58-11.31), NLR was 0.10 (95% CI: 0.03-0.36), DOR was 52.52 (95% CI: 10.02-275.42), and AUC was 0.93 (95% CI: 0.90-0.95), indicating that miR-375 is effective at detecting liver cancer.Conclusions: According to our meta-analysis, measuring serum miR-375 has high sensitivity and specificity, which will facilitate its clinical application in liver cancer monitoring.
机译：背景:肝癌是最之一经常诊断恶性肿瘤,非常高的发病率。与现有的方法和癌症是困难迫切需要改进的生物标志物。研究建立了联系mir - 375异常表达与肝癌。因此,我们进行了系统的分析评价是否可以用作mir - 375肝癌的筛查工具检测。搜索,研究调查mir - 375的表达在血清定量实时反向一(存在)方法被包括在内在这项研究中。肝癌和534没有肝癌)被招募。肝癌的检测评估敏感性,特异性,阳性可能性比率(PLR),阴性似然比(NLR),诊断比值比(金龟子),曲线下的面积(AUC)。mir - 375的特异性检测肝脏癌症是0.91(95%可信区间[CI]:分别。5.40(95%置信区间:2.58—-11.31),NLR为0.10(95%置信区间CI:和AUC为0.93(95%置信区间:0.90—-0.95),指示有效地检测肝脏mir - 375癌症。荟萃分析,测量血清mir - 375高敏感性和特异性,促进肝的临床应用癌症监测。

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