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首页> 外文期刊>Genetic testing and molecular biomarkers >NUTF2 as a Prognostic Indicator and Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma
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NUTF2 as a Prognostic Indicator and Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma

机译：NUTF2作为头颈部鳞状细胞癌的预后指标和潜在治疗靶点

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Aim: To identify genes associated with the prognosis of head and neck squamous cell carcinoma (HNSC) and potential molecular targets for therapy.Materials and Methods: Gene Expression Profiling Interactive Analysis, Human Protein Atlas, University of ALabama at Birmingham CANcer, LinkedOmics, cBioPortal, Cell Counting Kit 8, and polymerase chain reaction were used in this study.Results: The expression level of nuclear transport factor 2 (NUTF2) was elevated in HNSC tissues and was associated with poor prognosis in HNSC patients. NUTF2-targeted intervention inhibited the proliferation of HNSC cells. SEC61G, which was positively correlated with NUTF2, was decreased in HNSC cells with NUTF2 suppression.Conclusions: NUTF2 may be correlated with the prognosis and development of HNSC, laying the foundation for future studies on the potential role of NUTF2 in HNSC.
机译：目的:确定相关基因头颈鳞状细胞的预后癌(HNSC)和潜在的分子靶点为治疗。表达分析互动分析,人类蛋白质图谱,阿拉巴马大学伯明翰癌症、LinkedOmics cBioPortal,细胞计算设备8和聚合酶链反应被用于这项研究。水平的核运输因子2 (NUTF2)升高HNSC组织和有关HNSC患者的不良预后。干预抑制HNSC扩散细胞。与NUTF2 HNSC细胞减少NUTF2抑制。相关的预后和发展HNSC,为未来的研究打下了基础在HNSC NUTF2的潜在作用。

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