...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genetic testing and molecular biomarkers >LINC00116 Is a Novel Prognostic Biomarker of Nonsmall Cell Lung Cancer
【24h】

LINC00116 Is a Novel Prognostic Biomarker of Nonsmall Cell Lung Cancer

机译：LINC00116是非小细胞肺癌的新型预后生物标志物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: Lung cancer is the most malignant respiratory cancer with an undesirable prognosis. Emerging evidence shows that long noncoding RNAs (lncRNAs) can regulate lung cancer development. Currently, the role of LINC00116, a novel lncRNA, in lung cancer is unknown. This study was designed to evaluate the association and clinical significance between the level of LINC00116 and lung cancer.Materials and Methods: In the present study, 19 paired lung cancer and non-cancerous adjacent tissues were collected from lung cancer patients to measure the expression of LINC00116 by quantitative reverse transcription-polymerase chain reaction and Microarray analysis (Oncomine and CCLE). Clinicopathological features of patients were obtained to analyze their relationships with LINC00116 expression levels. Kaplan-Meier survival analysis was used to analyze the prognosis.Results: LINC00116 expression was upregulated in lung cancer. Furthermore, we found that LINC00116 expression was correlated with pT factor, pN factor, pTNM stage, smoking history, differentiation, and Ki-67 labeling index (p < 0.05). In addition, Kaplan-Meier survival analysis showed that high levels of LINC00116 expression were associated with poorer overall survival (OS), progression-free survival (PFS) and first progression (FP) (p < 0.05) of lung cancer patients.Conclusions: Our study provided evidence that LINC00116 is upregulated in lung cancer tissues and can predict poor survival. It might also be able to serve as a therapeutic target. The Clinical Trial Registration number 2022-020.
机译：目的:肺癌是最恶性的呼吸道癌症预后不良。新兴证据显示长非编码rna(lncRNAs)可以调节肺癌发展。目前,LINC00116的角色,小说lncRNA,肺癌是未知的。旨在评估协会和临床LINC00116和之间的意义肺癌。研究中,19个肺癌和非配对相邻组织收集于肺癌病人测量LINC00116的表达通过定量逆转transcription-polymerase连锁反应和微阵列分析(Oncomine和CCLE)。患者得到分析与LINC00116表达水平的关系。kaplan meier生存分析被用来对预后进行分析。在肺癌表达调节。此外,我们发现LINC00116表达式是与pT相关因素,pN因子,pTNM吗阶段,吸烟史、分化、和ki - 67标记指数(p < 0.05)。kaplan meier生存分析显示,高LINC00116表达水平有关贫穷总生存期(OS),无进展生存(PFS)和第一进展(FP)肺癌的(p < 0.05)病人。LINC00116调节在肺癌组织和可以预测可怜的生存。也可以作为治疗目标。临床试验注册号码2022 - 020。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号