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首页> 外文期刊>Genetic testing and molecular biomarkers >Recurrence Rate for Isolated Elevated Maternal Serum Alpha-Fetoprotein Levels and Pregnancy Outcomes
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Recurrence Rate for Isolated Elevated Maternal Serum Alpha-Fetoprotein Levels and Pregnancy Outcomes

机译：单纯性母体血清甲胎蛋白水平升高的复发率和妊娠结局

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Objective: To examine the rate of recurrence for elevated isolated maternal serum alpha-fetoprotein (MSAFP) and its associated adverse outcomes during a subsequent pregnancy.Materials and Methods: A retrospective cohort study of pregnant multiparous women who had elevated MSAFP levels during an initial and a subsequent pregnancy between 1994 and 2020.Results: Twenty-seven out of 344 (7.8%) women with elevated MSAFP had recurrent elevated MSAFP in a subsequent pregnancy. Four women were excluded due to missing data. Of the 23 women included, 5 (22%) had fetal growth restriction (FGR), 2 (9%) had pre-eclampsia, 9 (35%) had preterm births, and 2 (9%) had fetal death/miscarriage in their subsequent pregnancy. Looking at individual outcomes, 60% of women had recurrence of preterm labor, 33% had recurrence of fetal death, and 25% had recurrence of FGR.Conclusion: Women with elevated MSAFP levels during an initial pregnancy should be informed during preconception counseling about their risk of recurring elevated MSAFP and its associated adverse outcomes risks.
机译：目的:研究复发的速度高架孤立孕产妇血清甲胎蛋白(MSAFP)及其相关的在随后的不良结果怀孕。队列研究的多产的妇女怀孕MSAFP水平升高在最初和一个了吗随后的妊娠1994年间2020.女性与高架MSAFP复发性升高MSAFP在随后的怀孕。排除由于缺失的数据。包括5(22%)胎儿生长受限(FGR), 2(9%)有先兆子痫,9 (35%)早产,胎儿2 (9%)死亡/在随后的妊娠流产。看个人的结果,60%的女性再次发生早产,33%有复发胎儿死亡,25%的复发FGR。在怀孕最初应该知情在偏见对他们的风险咨询反复出现的高架MSAFP及其相关不良结果的风险。

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