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首页> 外文期刊>Archives of pathology & laboratory medicine >Meta-analysis of clinical studies of diagnostic tests: developments in how the receiver operating characteristic 'works'.
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Meta-analysis of clinical studies of diagnostic tests: developments in how the receiver operating characteristic 'works'.

机译：诊断测试临床研究的荟萃分析：接收器工作特性“工作原理”的发展。

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摘要

Meta-analytic summaries are needed on clinical studies of diagnostic tests. Meta-analyses on clinical studies of diagnostic tests commonly use the receiver operating characteristic method, which differs conceptually and computationally from the more widely known meta-analytic methods applicable in other contexts, such as in studies of randomized controlled trials. Important conceptual differences for clinical studies of diagnostic tests versus randomized controlled trials are that the study subpopulations are not defined by random allocation and the test threshold typically varies across studies to accommodate "rule in" versus "rule out" testing strategies. The receiver operating characteristic method has evolved substantially in the past decade, and the most recent approaches use multilevel regression methods that require iterative computational solutions to estimate the influence of the study-level variables. Using current methodology, a meta-analysis on clinical studies of diagnostic tests can address questions relevant to the clinical application of a diagnostic test that cannot be answered at the level of the individual study.
机译：诊断测试的临床研究需要荟萃分析摘要。对诊断测试的临床研究进行的荟萃分析通常使用接收者操作特征方法，该方法在概念和计算上与适用于其他情况的更广为人知的荟萃分析方法不同，例如在随机对照试验的研究中。对于诊断测试与随机对照测试的临床研究，重要的概念差异在于，研究亚群的定义不是随机分配的，并且测试阈值通常在各个研究中有所不同，以适应“原汁原味”与“原汁原味”的检测策略。接收器工作特征方法在过去十年中已经有了很大的发展，最近的方法使用多级回归方法，该方法需要迭代计算解决方案来估计研究级变量的影响。使用当前的方法，对诊断测试的临床研究进行荟萃分析可以解决与诊断测试的临床应用相关的问题，而这些问题在单个研究水平上是无法回答的。

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