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首页> 外文期刊>Archives of pharmacal research >Orthogonal array design for antidepressant compatibility of polysaccharides from Banxia-Houpu decoction, a traditional Chinese herb prescription in the mouse models of depression.
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Orthogonal array design for antidepressant compatibility of polysaccharides from Banxia-Houpu decoction, a traditional Chinese herb prescription in the mouse models of depression.

机译：正交阵列设计用于半夏厚朴汤的多糖的抗抑郁相容性，半夏厚朴汤是抑郁症小鼠模型中的中药处方。

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The present study investigated antidepressant-like interaction of five herb polysaccharide fractions from Banxia-Houpu decoction, composed of rhizome pinelliae (PRP), magnolia bark (PMB), poria (PPO), ginger rhizome (PGR) and folium perillae (PFP) by a L(16)(2(5)) orthogonal array design with a two-factor interaction in the tail suspension and forced swimming and tests (TST, FST) in mice. Serotonin (5-HT) and dopamine (DA) levels in whole mouse brain were simultaneously examined after the FST exposure. Polysaccharides PMB, PPO, PFP, and interactions of PRP x PGR, PMB x PFP, PPO x PFP reduced immobility in the mouse FST. Furthermore, PMB and PPO were two principal components of polysaccharides elevating brain 5-HT levels. PFP was an adjuvant component elevating brain DA levels. These results demonstrated that ineffective PRP exhibited antidepressant-like effects when combined with another ineffective PGR, and PFP played a role in assisting effects of PMB and PPO. Therefore, PMB x PFP and PPO x PFP interactions on antidepressant-like effects were the cores in compatibility of polysaccharides from Banxia-Houpu decoction by attenuating abnormalities in the serotonergic and dopaminergic system functions in animal models of depression.
机译：本研究研究了半夏-厚朴汤中的五种草药多糖类成分的抗抑郁样相互作用，该成分由半夏（PRP），木兰（PMB），po（PPO），姜根茎（PGR）和紫苏（PFP）组成。 L（16）（2（5））正交阵列设计，在小鼠的尾部悬吊和强迫游泳和测试（TST，FST）中具有两因素相互作用。 FST暴露后，同时检查整个小鼠大脑中的血清素（5-HT）和多巴胺（DA）水平。多糖PMB，PPO，PFP以及PRP x PGR，PMB x PFP，PPO x PFP的相互作用降低了小鼠FST的固定性。此外，PMB和PPO是提高大脑5-HT水平的多糖的两个主要成分。 PFP是提高脑DA水平的辅助成分。这些结果表明，无效的PRP与另一种无效的PGR结合时表现出抗抑郁样作用，而PFP在辅助PMB和PPO的作用中发挥作用。因此，通过抑制抑郁动物模型中血清素能和多巴胺能系统功能的异常，使PMB x PFP和PPO x PFP相互作用具有抗抑郁样作用，是半夏-厚朴汤多糖的相容性的核心。

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