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首页> 外文期刊>Archives of pharmacal research >Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.
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Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.

机译：水飞蓟素纳米乳液对四氯化碳诱导的肝损伤的影响。

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摘要

Silymarin is a complex mixture of four flavonolignan isomers (silybin, isosilybin, silydianin and silychristin) obtained from 'milk thistle' (Silybum marianum). This plant compound is used almost exclusively for hepatoprotection. Because of its low and poor oral bioavailability, silymarin was formulated as a nanoemulsion to increase its solubility (and so its oral bioavailability) as well as therapeutic activity. The present study assessed the hepatoprotective activity on Wistar rats by determining biochemical parameters and histopathological properties of the nanoemulsion formulation of silymarin against carbon tetrachloride (CCl(4))-induced hepatotoxicity. Hepatoprotective activity was evaluated by the activity of serum alkaline phosphatase, alanine transaminase and aspartate transaminase; antioxidative defence markers (concentration of reduced glutathione); oxidative stress parameter (thiobarbituric acid reactive substances) and liver histopathology. The nanoemulsion-treated group showed significant decreases in glutamate oxaloacetate transaminase, pyruvate transaminase, alkaline phosphotase, total bilirubin and tissue lipid peroxides and increased total protein, albumin, globulin and tissue glutathione as compared to toxicant. The results indicate an excellent potential of the nanoemulsion formulation for the reversal of CCl(4)-induced liver toxicity in rats as compared to standard silymarin.
机译：水飞蓟素是从“水飞蓟”（水飞蓟）中获得的四种黄酮木脂素异构体（水飞蓟宾，异水飞蓟宾，水飞蓟素和水飞蓟素）的复杂混合物。这种植物化合物几乎专门用于肝保护。由于水飞蓟素的口服生物利用度较低且较差，因此被配制为纳米乳剂，以提高其溶解度（以及口服生物利用度）以及治疗活性。本研究通过确定水飞蓟素纳米乳液制剂对四氯化碳（CCl（4））诱导的肝毒性的生化参数和组织病理学特性，评估了对Wistar大鼠的保肝活性。通过血清碱性磷酸酶，丙氨酸转氨酶和天冬氨酸转氨酶的活性来评估保肝活性。抗氧化防御标志物（还原型谷胱甘肽浓度）;氧化应激参数（硫代巴比妥酸反应性物质）和肝脏组织病理学。与有毒物质相比，纳米乳液治疗组的谷氨酸草酰乙酸转氨酶，丙酮酸转氨酶，碱性磷酸酶，总胆红素和组织脂质过氧化物显着降低，总蛋白，白蛋白，球蛋白和组织谷胱甘肽增加。结果表明，与标准水飞蓟素相比，纳米乳液制剂具有极好的潜力，可逆转CCl（4）诱导的大鼠肝毒性。

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