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Studies of the microbial metabolism of flavonoids extracted from the leaves of Diospyros kaki by intestinal bacteria

机译：肠道细菌提取柿柿叶中黄酮类化合物的微生物代谢研究

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Flavonoid glycosides are metabolized by intestinal bacteria, giving rise to a wide range of phenolic acids that may exert systemic effects in the body. The microbial metabolism of flavonoids extracted from the leaves of Diospyros kaki (FLDK) by intestinal bacteria was investigated in vitro. High-performance liquid chromatography/linear trap quadrupole orbitrap mass spectrometry was performed to analyze the metabolites of flavonoids in vivo using Xcalibur2.1 software. The results showed that the levels of flavonoid glycosides and flavonoid aglycones decreased rapidly in the process of microbial metabolism by intestinal bacteria in vitro, and the metabolic rate may be related to the concentration of intestinal bacteria in the culture solution. In vivo metabolites of FLDK were detected in rat plasma and urine after oral administration of FLDK. Eight flavonoids were identified in the urine, and three were identified in the plasma; however, flavonoid aglycones were not found in the plasma.
机译：类黄酮糖苷被肠道细菌代谢，产生多种酚酸，可能在体内发挥全身作用。体外研究了由肠道细菌从柿（Diospyros kaki）（FLDK）叶片中提取的黄酮类化合物的微生物代谢。使用Xcalibur2.1软件进行了高效液相色谱/线性阱四极杆轨道质谱仪分析体内的类黄酮代谢物。结果表明，在体外肠道细菌对微生物的代谢过程中，类黄酮苷和类黄酮苷元的含量迅速降低，代谢率可能与培养液中肠道细菌的浓度有关。口服FLDK后，在大鼠血浆和尿液中检测到FLDK的体内代谢产物。在尿液中鉴定出了8种黄酮，在血浆中鉴定出了3种。然而，血浆中未发现类黄酮苷元。

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