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首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Serotyping for an extended anti-citrullinated peptide autoantibody panel does not add value to CCP2 testing for diagnosing RA in an early undifferentiated arthritis cohort.
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Serotyping for an extended anti-citrullinated peptide autoantibody panel does not add value to CCP2 testing for diagnosing RA in an early undifferentiated arthritis cohort.

机译：延长抗瓜氨酸肽自身抗体检测的血清分型并不能增加CCP2检测在早期未分化关节炎人群中诊断RA的价值。

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摘要

The now widely employed CCP2 assay, which detects circulating autoantibodies to a panel of synthetic, cyclic citrul-linated peptides, carries a positive predictive value of 0.93 for rheumatoid arthritis (RA) among early undifferentiated arthritis (UA) patients, thus providing a cornerstone of recently evolved scoring systems that predict and classify early RA. However, approximately 80% of newly presenting UA patients are anti-CCP2-negative and a quarter of these evolve into RA within 3 years, thus experiencing diagnostic delay. The peptides used in the CCP2 assay do not necessarily correspond to in vivo generated proteins, yet citrulli-nated antigens of putative pathophysiological relevance have recently been described in association with specific circulating autoantibodies in RA. Therefore, we hypothesised that the detection of one or any such autoantibodies, as well as those against filaggrin components of the CCP1 assay, IgA or IgM rheumatoid factor (RP), might add to the diagnostic utility of CCP2 testing alone in predicting RA progression among early UA patients.
机译：现在广泛使用的CCP2检测可检测到一组合成​​的环状瓜氨酸环化肽的循环自身抗体，在早期未分化关节炎（UA）患者中对类风湿关节炎（RA）的阳性预测值为0.93，因此为最近发展起来的评分系统，可以对早期RA进行预测和分类。但是，新近出现的UA患者中约有80％是抗CCP2阴性的，其中四分之一在3年内演变为RA，因此出现了诊断延迟。 CCP2分析中使用的肽不一定与体内产生的蛋白质相对应，但是最近已证明与病理生理相关的瓜氨酸化抗原与RA中的特定循环自身抗体有关。因此，我们假设检测一种或任何此类自身抗体以及针对CCP1分析，IgA或IgM类风湿因子（RP）的丝聚蛋白成分的自身抗体，可能会增加CCP2检测的诊断效用，从而预测RA的进展。早期UA患者。

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