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首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >NSAIDs and radiographic progression in ankylosing spondylitis: Bagging big game with small arms?
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NSAIDs and radiographic progression in ankylosing spondylitis: Bagging big game with small arms?

机译：非甾体抗炎药和强直性脊柱炎的放射学进展：用小武器装袋大游戏？

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摘要

This study was designed to test the hypothesis that the sensory innervation of bone might play an important role in sensing and responding to low-intensity pulsed ultrasound and explain its effect in promoting fracture healing. In 112 rats a standardised mid-shaft tibial fracture was created, supported with an intramedullary needle and divided into four groups of 28. These either had a sciatic neurectomy or a patellar tendon resection as control, and received the ultrasound or not as a sham treatment. Fracture union, callus mineralisation and remodelling were assessed using plain radiography, peripheral quantitative computed tomography and histomorphology. Daily ultrasound treatment significantly increased the rate of union and the volumetric bone mineral density in the fracture callus in the neurally intact rats (p = 0.025), but this stimulating effect was absent in the rats with sciatic neurectomy. Histomorphology demonstrated faster maturation of the callus in the group treated with ultrasound when compared with the control group. The results supported the hypothesis that intact innervation plays an important role in allowing low-intensity pulsed ultrasound to promote fracture healing.
机译：本研究旨在检验以下假设：骨骼的感觉神经支配可能在感知和响应低强度脉冲超声中起重要作用，并解释其在促进骨折愈合中的作用。在112只大鼠中，创建了标准的胫骨中轴骨折，并由髓内针支持，分为四组，每组28只。这些均接受坐骨神经切除术或a腱切断术作为对照，并且接受超声或不接受假治疗。骨折愈合，愈伤组织矿化和重塑采用平片，外围定量计算机断层扫描和组织形态学进行评估。每日超声治疗显着提高了神经完好的大鼠的骨折call中的愈合率和骨矿物质体积密度（p = 0.025），但在坐骨神经切除术大鼠中没有这种刺激作用。与对照组相比，超声治疗组的组织形态学表明愈伤组织成熟更快。结果支持以下假设：完整的神经支配在允许低强度脉冲超声促进骨折愈合中起重要作用。

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