Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis

Schelbergen R. F. P.; de Munter W.; van den Bosch M. H. J.; Lafeber F. P. J. G.; Sloetjes A.; Vogl T.; Roth J.; van den Berg W. B.; van der Kraan P. M.; Blom A. B.; van Lent P. L. E. M.

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis

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Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis

机译：Alarmins S100A8 / S100A9会加剧实验性骨关节炎中的骨赘形成并预测人类早期症状性骨关节炎中的骨赘进展

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Objective Alarmins S100A8 and S100A9 are major products of activated macrophages regulating cartilage damage and synovial activation during murine and human osteoarthritis (OA). In the current study, we investigated whether S100A8 and S100A9 are involved in osteophyte formation during experimental OA and whether S100A8/A9 predicts osteophyte progression in early human OA.

机译：目的Alarmins S100A8和S100A9是活化的巨噬细胞的主要产品，可调节鼠类和人类骨关节炎（OA）期间的软骨损伤和滑膜活化。在当前的研究中，我们调查了在实验性OA期间S100A8和S100A9是否与骨赘形成有关，以及S100A8 / A9是否预测人类早期OA中的骨赘进展。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2016年第1期|共8页
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Schelbergen R. F. P.; de Munter W.; van den Bosch M. H. J.; Lafeber F. P. J. G.; Sloetjes A.; Vogl T.; Roth J.; van den Berg W. B.; van der Kraan P. M.; Blom A. B.; van Lent P. L. E. M.;
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中图分类免疫性疾病;
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1. Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis [J] . Schelbergen R. F. P., de Munter W., van den Bosch M. H. J., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2016,第1期

机译：Alarmins S100A8 / S100A9会加剧实验性骨关节炎中的骨赘形成并预测人类早期症状性骨关节炎中的骨赘进展
2. Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-Data from the Osteoarthritis Initiative- [J] . Okada Kentaro, Yamaguchi Satoshi, Sato Yasunori, Journal of orthopaedic science : . 2019,第1期

机译：与骨关节炎术中膝关节骨关节炎发病率的预测生物标志物进行半核挤压和骨赘形成术中的预测生物标志物 -
3. Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative [J] . Katsuragi J., Sasho T., Yamaguchi S., Osteoarthritis and cartilage . 2015,第3期

机译：X线平片上隐匿的骨赘形成是48个月后膝盖骨关节炎发展的预测因素-骨关节炎计划的数据
4. Detecting Osteophytes in Radiographs of the Knee to Diagnose Osteoarthritis [C] . Jessie Thomson, Terence ONeill, David Felson, International conference on medical image computing and computer assisted intervention;International workshop on machine learning in medical imaging . 2016

机译：在膝关节X光片中检测骨赘以诊断骨关节炎
5. Intra-Articular Delivery of Encapsulated Human Mesenchymal Stem Cells Reduces Osteoarthritis Progression in a Rat Model [D] . McKinney, Jay Michael, Jr. 2017

机译：囊内人间充质干细胞的关节内递送减少大鼠模型的骨关节炎进展
6. ALPHA-CTX is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis [O] . Janet L Huebner, Anne C Bay-Jensen, Kim M Huffman, -1

机译：ALPHA-CTX与软骨下骨转换有关并预测骨关节炎中关节间隙变窄和骨赘的进展
7. Alarmins S100A8/S100A9 stimulate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in the check cohort of early human osteoarthritis patients [O] . Schelbergen R.F., de Munter W., van den Bosch M.H., 2014

机译：Alarmins S100A8 / S100A9在实验性骨关节炎中刺激骨赘形成并预测早期人类骨关节炎患者检查队列中的骨赘进展

Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis

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