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首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls
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Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls

机译：类风湿关节炎和非类风湿关节炎对照中低密度脂蛋白和类风湿关节炎遗传因素与低密度脂蛋白水平之间的关联

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Objectives: While genetic determinants of low density lipoprotein (LDL) cholesterol levels are well characterised in the general population, they are understudied in rheumatoid arthritis (RA). Our objective was to determine the association of established LDL and RA genetic alleles with LDL levels in RA cases compared with non-RA controls. Methods: Using data from electronic medical records, we linked validated RA cases and non-RA controls to discarded blood samples. For each individual, we extracted data on: first LDL measurement, age, gender and year of LDL measurement. We genotyped subjects for 11 LDL and 44 non-HLA RA alleles, and calculated RA and LDL genetic risk scores (GRS). We tested the association between each GRS and LDL level using multivariate linear regression models adjusted for age, gender, year of LDL measurement and RA status. Results: Among 567 RA cases and 979 controls, 80% were female and mean age at the first LDL measurement was 55 years. RA cases had significantly lower mean LDL levels than controls (117.2 vs 125.6 mg/dl, respectively, p0.0001). Each unit increase in LDL GRS was associated with 0.8 mg/dl higher LDL levels in both RA cases and controls (p=3.0×10-7). Each unit increase in RA GRS was associated with 4.3 mg/dl lower LDL levels in both groups ( p=0.01). Conclusions: LDL alleles were associated with higher LDL levels in RA. RA alleles were associated with lower LDL levels in both RA cases and controls. As RA cases carry more RA alleles, these findings suggest a genetic basis for epidemiological observations of lower LDL levels in RA.
机译：目的：虽然低密度脂蛋白（LDL）胆固醇水平的遗传决定因素在一般人群中已得到很好的表征，但在类风湿关节炎（RA）中尚未对其进行研究。我们的目标是确定与非RA对照相比，RA患者中已建立的LDL和RA遗传等位基因与LDL水平的相关性。方法：使用电子病历中的数据，将经过验证的RA病例和非RA对照与丢弃的血液样本相关联。对于每个人，我们提取以下数据：第一次LDL测量，年龄，性别和LDL测量年份。我们对11个LDL和44个非HLA RA等位基因进行了基因分型，并计算了RA和LDL遗传风险评分（GRS）。我们使用针对年龄，性别，LDL测量年限和RA状态进行调整的多元线性回归模型，测试了每个GRS与LDL水平之间的关联。结果：在567例RA病例和979例对照中，女性占80％，首次LDL测量的平均年龄为55岁。 RA病例的平均LDL水平明显低于对照组（分别为117.2和125.6 mg / dl，p <0.0001）。在RA病例和对照中，LDL GRS的每增加一个单位都会使LDL水平升高0.8 mg / dl（p = 3.0×10-7）。在两组中，RA GRS的每增加一个单位都使LDL水平降低4.3 mg / dl（p = 0.01）。结论：LDL等位基因与RA中较高的LDL水平有关。在RA病例和对照中，RA等位基因均与较低的LDL水平相关。由于RA病例携带更多的RA等位基因，这些发现为RA中低LDL水平的流行病学观察提供了遗传基础。

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