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首页> 外文期刊>Arteriosclerosis, thrombosis, and vascular biology >Increased thrombin generation is associated with acute ischemic stroke but not with coronary heart disease in the elderly: the three-city cohort study.
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Increased thrombin generation is associated with acute ischemic stroke but not with coronary heart disease in the elderly: the three-city cohort study.

机译：三城市队列研究显示，凝血酶产生增加与老年人急性缺血性卒中有关，但与冠心病无关。

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OBJECTIVE: A high thrombin generation level has been associated with the risk of venous thrombosis. Whether changes in this biomarker are relevant to arterial disease remains unknown. We investigated the association of thrombin generation with coronary heart disease (CHD) and acute ischemic stroke (AIS) in the elderly. METHODS AND RESULTS: We used data from the Three-City study, a prospective cohort including 9294 subjects aged >65 years. After 4 years of follow-up, a case-cohort study was established. Using the calibrated automated thrombography method, endogenous thrombin potential and peak height were measured in plasma samples of all CHD and AIS cases and a random sample of 1177 controls. We did not find any significant association between thrombin generation and CHD. In multivariate analyses, high levels of endogenous thrombin potential and peak height were associated with an increased risk of AIS (hazard ratio=1.16 [95% CI, 0.90 to 1.50] and 1.31 [95% CI, 1.01 to 1.69] for a 1 SD increase, respectively). Data also suggested that these associations might be more important in women (hazard ratio=1.55 [95% CI, 1.05 to 2.33] and 1.71 [95% CI, 1.11 to 2.63], respectively) than in men (P for interaction=0.04 and 0.08, respectively). CONCLUSIONS: Thrombin generation emerges as an independent predictor of AIS, particularly in women. Hypercoagulability may have an important role in the pathogenesis of AIS.
机译：目的：高凝血酶水平与静脉血栓形成的风险有关。该生物标志物的变化是否与动脉疾病有关仍是未知的。我们调查了老年人凝血酶产生与冠心病（CHD）和急性缺血性中风（AIS）的关系。方法和结果：我们使用了来自三城市研究的数据，这是一个前瞻性队列，包括9294名年龄> 65岁的受试者。经过4年的随访，建立了一项病例队列研究。使用校准的自动血栓成像方法，在所有CHD和AIS病例的血浆样本以及1177个对照的随机样本中测量了内源性凝血酶电位和峰高。我们没有发现凝血酶和冠心病之间的任何重大关联。在多变量分析中，高水平的内源性凝血酶电位和峰高与AIS的风险增加相关（1 SD的危险比= 1.16 [95％CI，0.90至1.50]和1.31 [95％CI，1.01至1.69]分别增加）。数据还表明，与女性相比，女性（危险比分别为1.55 [95％CI，1.05至2.33]和1.71 [95％CI，1.11至2.63]）的关联性可能比男性更重要（交互作用P = 0.04和分别为0.08）。结论：凝血酶的产生是AIS的独立预测因子，特别是在女性中。高凝性可能在AIS的发病机理中起重要作用。

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