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首页> 外文期刊>Brain imaging and behavior >Cognitive rehabilitation correlates with the functional connectivity of the anterior cingulate cortex in patients with multiple sclerosis
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Cognitive rehabilitation correlates with the functional connectivity of the anterior cingulate cortex in patients with multiple sclerosis

机译：多发性硬化症患者的认知康复与前扣带回皮质的功能连通性相关

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摘要

We investigated how resting state (RS) functional connectivity (FC) of the anterior cingulate cortex (ACC) correlates with cognitive rehabilitation in relapsing remitting multiple sclerosis (RRMS) patients. A neuropsychological assessment and RS fMRI at baseline and after 12 weeks were obtained from 20 RRMS patients, who were assigned randomly to undergo treatment (n = 10) (treatment group-TG), which entailed computer-assisted cognitive rehabilitation of attention/information processing and executive functions for 3 days/week, or not to receive any cognitive rehabilitation (n = 10) (control group-CG). Voxel-wise changes of ACC RS FC were assessed using SPM8. In both groups, at the two study time points, ACC activity was correlated with the bilateral middle and inferior frontal gyrus, basal ganglia, posterior cingulate cortex, cerebellum, precuneus, middle temporal gyrus, and inferior parietal lobule (IPL). At follow up, compared to baseline, the TG showed an increased FC of the ACC with the right middle frontal gyrus (MFG) and right IPL, while the CG showed a decreased FC of the ACC with the right cerebellum and right inferior temporal gyrus (ITG). A significant "treatment x time" interaction was found for the increased FC of the right IPL and for the decreased FC of the right ITG. In the TG only, significant correlations (p < 0.001) were found between improvement of PASAT performance and RS FC of the ACC with the right MFG (r = 0.88) and right IPL (r = 0.76). In MS, cognitive rehabilitation correlates with changes in RS FC of brain regions subserving the trained functions. fMRI might be useful to monitor rehabilitative strategies in MS.
机译：我们调查了前扣带回皮层（ACC）的静止状态（RS）功能连接性（FC）与复发缓解型多发性硬化症（RRMS）患者的认知康复之间的关系。对20名RRMS患者进行基线和12周后的神经心理学评估和RS fMRI，这些患者被随机分配接受治疗（n = 10）（治疗组TG），这需要注意力/信息处理的计算机辅助认知康复和执行功能每周3天，或者不接受任何认知康复（n = 10）（对照组CG）。使用SPM8评估ACC RS FC的按体素变化。在两组中，在两个研究时间点，ACC活性均与双侧中下额叶回，基底神经节，后扣带回皮层，小脑，前神经突，中颞回和下顶叶（IPL）相关。随访时，与基线相比，TG显示右中额回（MFG）和右IPL的ACC的FC增加，而CG则显示右小脑和颞下回的ACC的FC减少（ ITG）。对于正确的IPL的FC增加和正确的ITG的FC减少，发现了显着的“处理x时间”交互作用。仅在TG中，在右MFG（r = 0.88）和右IPL（r = 0.76）的情况下，PASAT性能的改善和ACC的RS FC之间存在显着相关性（p <0.001）。在MS中，认知康复与维持训练有素的功能的大脑区域RS FC的变化有关。 fMRI对监测MS的康复策略可能有用。

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