Different glycosyltransferases are involved in lipid glycosylation and protein N-glycosylation in the halophilic archaeon Haloferax volcanii.

Naparstek S; Vinagradov E; Eichler J

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Different glycosyltransferases are involved in lipid glycosylation and protein N-glycosylation in the halophilic archaeon Haloferax volcanii.

机译：嗜盐古细菌Haloferax volcanii中的脂质糖基化和蛋白质N-糖基化涉及不同的糖基转移酶。

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Both the lipid and the protein components of biological membranes can be modified by the covalent addition of polysaccharides. Whereas eukaryal and bacterial pathways of lipid and protein glycosylation are relatively well defined, considerably less is known of the parallel processes in Archaea. Recent efforts have identified glycosyltransferases involved in N-glycosylation of the surface-layer glycoprotein of the halophilic archaeon Haloferax volcanii. In the present study, the involvement of these same glycosyltransferases in the biosynthesis of Hfx. volcanii glycolipids was considered by performing nuclear magnetic resonance analysis of the glycolipid fraction of Hfx. volcanii cells deleted of genes encoding those glycosyltransferases, as well as the oligosaccharyltransferase, AglB. The results reveal that different glycosyltransferases are involved in the biosynthesis of N-linked glycoproteins and glycolipids in Archaea.

机译：可以通过共价添加多糖来修饰生物膜的脂质和蛋白质成分。尽管脂质和蛋白质糖基化的真核和细菌途径相对明确，但古细菌中的平行过程所知甚少。最近的努力已经鉴定出了与嗜盐古菌Haloferax volcanii的表面层糖蛋白的N-糖基化有关的糖基转移酶。在本研究中，这些相同的糖基转移酶参与了Hfx的生物合成。通过对Hfx的糖脂级分进行核磁共振分析来考虑使用Volcanii糖脂。火山细胞中缺失了编码那些糖基转移酶以及寡糖基转移酶AglB的基因。结果表明，古细菌中N-连接的糖蛋白和糖脂的生物合成涉及不同的糖基转移酶。

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《Archives of microbiology》 |2010年第7期|共4页
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Naparstek S; Vinagradov E; Eichler J;
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1. Different glycosyltransferases are involved in lipid glycosylation and protein N-glycosylation in the halophilic archaeon Haloferax volcanii. [J] . Naparstek S, Vinagradov E, Eichler J Archives of microbiology . 2010,第7期

机译：嗜盐古细菌Haloferax volcanii中的脂质糖基化和蛋白质N-糖基化涉及不同的糖基转移酶。
2. Defining the Topology of the N-Glycosylation Pathway in the Halophilic Archaeon Haloferax volcanii [J] . Noa Plavner, Jerry Eichler Journal of bacteriology . 2008,第24期

机译：定义嗜盐古细菌Haloferax volcanii中N-糖基化途径的拓扑
3. Defining the Topology of the N-Glycosylation Pathway in the Halophilic Archaeon Haloferax volcanii [J] . Noa Plavner, Jerry Eichler Journal of bacteriology . 2008,第24期

机译：定义嗜盐古细菌Haloferax volcanii中N-糖基化途径的拓扑
4. Case study: Application of mass spectrometry for evaluation of N-glycosylation, lipids and protein impurities in a plant-made influenza VLP vaccine. [C] . Genevieve Mercier, Nathalie Landry, Julie Boisvert, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：案例研究：质谱法在植物型流感VLP疫苗中施用N-糖基化，脂质和蛋白质杂质的评价。
5. Identification and characterization of N-glycosylation and structural genes involved in flagellation of methanogenic archaea from the genus Methanococcus [D] . Chaban, Bonnie Laura 2007

机译：鉴定和表征甲烷球菌属产甲烷菌古细菌鞭毛的N-糖基化和结构基因
6. Defining the Topology of the N-Glycosylation Pathway in the Halophilic Archaeon Haloferax volcanii [O] . Noa Plavner, Jerry Eichler 2008

机译：定义嗜盐古细菌Haloferax volcanii中N-糖基化途径的拓扑
7. Defining the Topology of the N-Glycosylation Pathway in the Halophilic Archaeon Haloferax volcanii▿ [O] . Plavner, Noa, Eichler, Jerry 2008

机译：定义嗜盐古细菌Haloferax volcanii中N-糖基化途径的拓扑
8. Post-translational Modification of Extremophilic Proteins: N-glycosylation in Archaea. [R] . Eichler, J. 2014

机译：极端蛋白质的翻译后修饰：古细菌中的N-糖基化。

Different glycosyltransferases are involved in lipid glycosylation and protein N-glycosylation in the halophilic archaeon Haloferax volcanii.

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