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首页> 外文期刊>Archives of Toxicology >Rapeseed oil-rich di, et alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics
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Rapeseed oil-rich di, et alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics

机译：富含菜籽油的di等会改变肝线粒体膜脂质组成并破坏生物能

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Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats were fed for 11, 22 and 33 days with a rapeseed oil-based diet and mitochondrial bioenergetics, and membrane composition were compared at each time point with a standard diet group. Considerable differences were noticed in mitochondrial membrane lipid composition, namely in terms of fatty acyl chains and relative proportions of phospholipid classes, the modified diet inducing a decrease in the saturated to unsaturated molar ratio and an increase in the phosphatidylcholine to phosphatidylethanolamine molar ratio. Mass spectrometry lipid analysis showed significant differences in the major species of cardiolipin, with an apparent increased incorporation of oleic acid as a result of exposure to the modified diet. Rats fed the modified diet during 22 days showed decreased hepatic mitochondrial state 3 respiration and were more susceptible to Ca2+-induced transition pore opening. Rapeseed oil-enriched di, et also appeared to promote a decrease in hydroperoxide production by the respiratory chain, although a simultaneous decrease in vitamin E content was detected. In conclusion, our data indicate that the rapeseed oil diet causes negative alterations on hepatic mitochondrial bioenergetics, which may result from membrane remodeling. Such alterations may have an impact not only on energy supply to the cell, but also on drug-induced hepatic mitochondrial liabilities.
机译：饮食与在细胞和亚细胞水平发生的生理变化直接相关。然而，饮食操纵对线粒体生理的作用仍在很大程度上未被探索。为了使饮食与线粒体膜组成和生物能学的改变相关联，Wistar-Han雄性大鼠以菜籽油为基础的饮食和线粒体生物能学喂养11、22和33天，并在每个时间点将膜组成与标准品进行比较饮食组。注意到线粒体膜脂质组成上的显着差异，即在脂肪酰基链和磷脂类别的相对比例方面，改良饮食引起饱和与不饱和摩尔比的降低以及磷脂酰胆碱与磷脂酰乙醇胺的摩尔比的增加。质谱脂质分析表明，在主要的心磷脂种类中存在显着差异，由于暴露于改良饮食中，油酸的掺入明显增加。在22天内喂食改良饮食的大鼠显示出肝线粒体3状态呼吸减少，并且更易受Ca2 +诱导的过渡孔开放的影响。尽管检测到维生素E含量同时下降，但富含菜籽油的di等人也似乎通过呼吸链促进了氢过氧化物的产生。总之，我们的数据表明菜籽油饮食会引起肝线粒体生物能学的负面变化，这可能是膜重塑造成的。这种改变不仅会影响细胞的能量供应，而且还会影响药物诱导的肝线粒体功能。

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