How the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response

CalabreseE.J.

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How the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response

机译：美国国家科学院如何在癌症风险评估方面误导国际社会：新发现挑战线性剂量反应的历史基础

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This paper extends several recent publications indicating that Hermann J. Muller: (1) Made deceptive statements during his Noble Prize Lecture on December 12, 1946, that were intended to promote the acceptance of the linear dose-response model for risk assessment for ionizing radiation and (2) that such actions of Muller were masked by a series of decisions by Muller's long-time colleague and esteemed radiation geneticist Curt Stern, affecting key publications in the mutation literature. Such actions further enhanced acceptance of the linearity dose-response model while preventing Muller's deceptions from being discovered. This paper provides documentation that Muller reinforced such practices within the scientific literature in the early 1950s, by supporting scientifically questionable actions of Stern. Detailed documentation is provided that demonstrates how these actions affected national and international risk assessment policy for ionizing radiation and chemical carcinogens via the recommendations of the National Academy of Sciences Biological Effects of Atomic Radiation committee in 1956, to adopt the linear dose-response model.

机译：本文扩展了一些最近的出版物，这些出版物表明Hermann J. Muller：（1）在1946年12月12日的诺贝尔奖演讲中做了具有欺骗性的陈述，旨在促进接受线性剂量反应模型进行电离辐射风险评估（2）Muller的长期同事和受尊敬的辐射遗传学家Curt Stern的一系列决定掩盖了Muller的这种行为，影响了突变文献中的关键出版物。这样的动作进一步增强了对线性剂量反应模型的接受，同时防止了穆勒的欺骗被发现。本文提供的文件显示，穆勒通过支持斯特恩的可疑科学行为，在1950年代初加强了科学文献中的此类实践。通过1956年美国国家科学院原子辐射生物学效应委员会的建议，采用线性剂量反应模型，提供了详细的文档，以说明这些行为如何影响国家和国际电离辐射和化学致癌物的风险评估政策。

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《Archives of Toxicology》 |2013年第12期|共19页
作者
CalabreseE.J.;
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正文语种 eng
中图分类毒物学（毒理学）;
关键词
Dose response; History of science; Linearity; Muller; Mutation; Risk assessment;

机译：剂量反应;科学史;线性;穆勒;突变;风险评估;

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1. Response to Letter of Ralph J Cicerone and Kevin Crowley regarding "how the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response." [DOI 10.1007/s00204-013-1105-6, Review Article] [J] . CalabreseE.J. Archives of Toxicology . 2014,第1期

机译：对Ralph J Cicerone和Kevin Crowley的信的回应，内容是“美国国家科学院如何在癌症风险评估方面误导国际社会：新发现挑战了线性剂量反应的历史基础。” [DOI 10.1007 / s00204-013-1105-6，评论文章]
2. How the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response [J] . CalabreseE.J. Archives of Toxicology . 2013,第12期

机译：美国国家科学院如何在癌症风险评估方面误导国际社会：新发现挑战线性剂量反应的历史基础
3. How the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response [J] . CalabreseE.J. Archives of Toxicology . 2013,第12期

机译：美国国家科学院如何在癌症风险评估方面误导国际社会：新发现挑战线性剂量反应的历史基础
4. National Academy of Science/National Research Council Report on Health Risks from Arsenic [C] . Robert A. Goyer American Water Works Association (AWWA) annual conference . 1999

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How the US National Academy of Sciences misled the world community on cancer risk assessment: New findings challenge historical foundations of the linear dose response

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