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首页> 外文期刊>Archives of Oral Biology >Photoactivated disinfection of Streptococcus intermedius through dentin disc at clinically relevant intervals: an in vitro study.
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Photoactivated disinfection of Streptococcus intermedius through dentin disc at clinically relevant intervals: an in vitro study.

机译：在临床相关的时间间隔内通过牙本质片对中间链球菌进行光活化消毒：一项体外研究。

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In this present study we have tested the impact of porfimer sodium (Photofrin, AXCAN PHARMA Inc., Quebec, Canada) photoactivated disinfection (PD) on cells of Streptococcus intermedius in suspension. In order to provide basic data to support future clinical studies of PD in dentistry the study used exposure to Quartz-tungsten-halogen (QTH) dental curing light for clinically relevant time periods to activate Photofrin and measured its effectiveness under a variety of conditions including activation through dentin hard tissue. S. intermedius was grown in planktonic suspension for 48h. Nine groups were formed: three control groups (1-3) and six experimental groups (4-9). Groups 4-6 tested the use of Photofrin treatment combined with QTH light at various intervals of irradiation (5, 15 and 60s). Groups 7-9 were similar to groups 4-6 with the exception that irradiation commenced through a dentin disc. Following treatment, bacteria were plated. Colony counts were measured following 72h incubation at 37 degrees C. Statistical analysis was carried out by one-way ANOVA at a 95% confidence level. A significant reduction in S. intermedius colony counts was observed for all experimental groups and one control group. The reduction in numbers of colonies in the experimental groups varied from 79.28 to 99.40% with an average of 94.61%. Reduction in viable bacterial cells indicated a strong relationship between power density and irradiation interval. When curing light energy density was lower due to the irradiation through the 1mm dentin disc, prolonged irradiation interval enhanced bacterial kill. In conclusion, where direct irradiation is not possible for PD treatment, irradiation through dentin may still be done successfully within a clinically relevant interval.
机译：在本研究中，我们已经测试了porfimer钠（Photofrin，AXCAN PHARMA Inc.，加拿大魁北克，加拿大）光活化消毒（PD）对中间链球菌悬浮细胞的影响。为了提供基础数据以支持未来牙科PD的临床研究，该研究在临床相关的时间段内使用了暴露于石英钨卤素（QTH）牙科光固化剂的光来激活Photofrin，并测量了其在包括激活在内的各种条件下的有效性通过牙本质硬组织。 intermedius在浮游悬浮液中生长48h。形成九个组：三个对照组（1-3）和六个实验组（4-9）。 4-6组在不同的照射间隔（5、15和60s）下测试了将Photofrin处理与QTH光结合使用的情况。第7-9组与第4-6组相似，除了通过牙本质盘照射开始。处理后，将细菌铺板。在37℃下孵育72h后测量菌落计数。通过单向方差分析以95％置信度进行统计分析。对于所有实验组和一个对照组，观察到中间链球菌菌落计数显着降低。实验组中菌落的减少从79.28％减少到99.40％，平均为94.61％。活细菌细胞的减少表明功率密度和照射间隔之间有很强的关系。当固化光的能量密度由于通过1mm牙本质盘的照射而降低时，延长的照射间隔会增强细菌杀灭力。总之，在无法进行PD治疗的直接照射中，通过牙本质照射仍可在临床相关间隔内成功完成。

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