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首页> 外文期刊>Arteriosclerosis, thrombosis, and vascular biology >Antithrombin-independent effects of heparins on fibrin clot nanostructure
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Antithrombin-independent effects of heparins on fibrin clot nanostructure

机译：肝素对纤维蛋白凝块纳米结构的抗凝血酶非依赖性作用

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Objective-: Because of the widespread clinical use of heparins, their effects on the enzymatic cascade are very well known. In contrast, little is known about the direct effect of heparins on the nanostructure of fibrin fibers, even though this nanostructure plays a major role in the mechanical strength and lysis of clots. This lack of reliable data can be correlated with the lack of a nonintrusive, quantitative method to determine this structure. We recently developed such a method that allows the simultaneous determination of the average fiber radius and the protein content using spectrometric data. In this study, we assessed the nanostructure of fibrin in a system composed of human thrombin and fibrinogen. Methods And Results-: We provide quantitative evidence showing that both unfractionated heparin and low molecular weight heparin directly alter the nanostructure of fibrin fibers independent of their other actions on the coagulation cascade; as expected, the pentasaccharide fondaparinux has no effect. Conclusion-: Our results show that in addition to the effect of heparin on the coagulation cascade, modifications of the fibrin nanostructure may also contribute to improved fibrinolysis.
机译：目的-：由于肝素在临床上的广泛使用，它们对酶促级联反应的作用是众所周知的。相反，关于肝素对血纤蛋白纤维的纳米结构的直接作用知之甚少，即使这种纳米结构在机械强度和血块溶解中起主要作用。缺乏可靠的数据可能与缺乏确定该结构的非介入式定量方法相关。我们最近开发了一种方法，该方法允许使用光谱数据同时确定平均纤维半径和蛋白质含量。在这项研究中，我们评估了由人凝血酶和纤维蛋白原组成的系统中纤维蛋白的纳米结构。方法和结果：我们提供了定量证据，表明普通肝素和低分子量肝素均可直接改变血纤蛋白纤维的纳米结构，而与它们对凝血级联反应的其他作用无关。不出所料，五糖磺达肝素没有作用。结论-：我们的结果表明，除了肝素对凝血级联反应的影响外，纤维蛋白纳米结构的修饰也可能有助于改善纤维蛋白溶解。

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