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首页> 外文期刊>Arteriosclerosis, thrombosis, and vascular biology >Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report
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Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report

机译:从2型糖尿病的组织液中分离的高密度脂蛋白的胆固醇外排能力受损

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摘要

Objective-Patients with type 2 diabetes mellitus (T2D) have an increased risk of cardiovascular disease, the mechanism of which is incompletely understood. Their high-density lipoprotein (HDL) particles in plasma have been reported to have impaired cholesterol efflux capacity. However, the efflux capacity of HDL from interstitial fluid (IF), the starting point for reverse cholesterol transport, has not been studied. We here investigated the cholesterol efflux capacity of HDL from IF and plasma from T2D patients and healthy controls.
机译:患有2型糖尿病(T2D)的目标患者的心血管疾病风险增加,其机理尚不完全清楚。据报道,它们在血浆中的高密度脂蛋白(HDL)颗粒损害了胆固醇的流出能力。但是,尚未研究HDL从组织液(IF)流出的能力,这是胆固醇反向转运的起点。我们在这里研究了中频高密度脂蛋白的胆固醇外流能力,以及来自T2D患者和健康对照组的血浆。

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