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首页> 外文期刊>Archives of women's mental health >Does family history of depression predict major depression in midlife women? Study of Women's Health Across the Nation Mental Health Study (SWAN MHS)
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Does family history of depression predict major depression in midlife women? Study of Women's Health Across the Nation Mental Health Study (SWAN MHS)

机译：抑郁症的家族史是否可以预测中年女性的严重抑郁症？全国心理健康研究中的妇女健康研究（SWAN MHS）

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This study aims to determine whether family history of depression predicts major depression in midlife women independent of psychosocial and health profiles at midlife. Participants were 303 African American and Caucasian women (42-52 years at baseline) recruited into the Study of Women's Health Across the Nation (SWAN) and the Women's Mental Health Study (MHS) in Pittsburgh. Major depression was assessed annually with the Structured Clinical Interview for DSM-IV. Family mental health history was collected at the ninth or tenth follow-up. Multivariable logistic regression was used to determine whether family history of depression predicted major depression in midlife, adjusting for covariates. The odds of experiencing major depression during the study were three times greater for those with a family history than for those without a family history (OR=3.22, 95 % CI=1.95-5.31). Family history predicted depression (OR=2.67, 95 % CI=1.50-4.78) after adjusting for lifetime history of depression, age, trait anxiety, chronic medical conditions, and stressful life events. In analyses stratified by lifetime history of depression, family history significantly predicted depression only among women with a lifetime history of depression. Family history of depression predicts major depression in midlife women generally, but particularly in those with a lifetime history of depression prior to midlife.
机译：这项研究旨在确定抑郁症的家族史是否可以预测中年妇女的严重抑郁，而与中年人的社会心理和健康状况无关。参加研究的303名非洲裔美国妇女和高加索妇女（基线时为42-52岁）被纳入匹兹堡全国妇女健康研究（SWAN）和妇女心理健康研究（MHS）。每年都会通过《 DSM-IV结构性临床访谈》对严重抑郁症进行评估。在第九或第十次随访中收集家庭心理健康史。多变量对数回归用于确定抑郁症家族史是否预测了中年的严重抑郁症，并调整了协变量。具有家族史的人在研究期间经历严重抑郁的几率比没有家族史的人大三倍（OR = 3.22，95％CI = 1.95-5.31）。在调整了抑郁症的一生史，年龄，性格焦虑，慢性病和压力性生活事件后，家族史预测抑郁症（OR = 2.67，95％CI = 1.50-4.78）。在根据一生的抑郁症历史分层的分析中，家族史仅在有一生抑郁症历史的女性中显着预测了抑郁症。抑郁症的家族病史通常预示着中年妇女会出现严重的抑郁症，但尤其是那些在中年之前有终生抑郁症的妇女。

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