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首页> 外文期刊>Archives of Toxicology >Nanosized TiO2 caused minor airflow limitation in the murine airways.
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Nanosized TiO2 caused minor airflow limitation in the murine airways.

机译：纳米二氧化钛导致鼠气道的气流受限。

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The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (0.5 h) to in situ generated TiO(2) (primary particle size 20 nm; geometric mean diameters of 91, 113, and 130 nm at mass concentrations of 8, 20, and 30 mg/m(3), respectively; crystal phase anatase + brookite (3:1)) caused airflow limitation in the conducting airways at each studied exposure concentration, which was shown as a reduction in expiratory flow, being at the lowest 73% of baseline. The response was not dose dependent. Repeated exposures (altogether 16 h, 1 h/day, 4 days/week for 4 weeks) to TiO(2) at mass concentration of 30 mg/m(3) caused as intense airflow limitation effect as the single exposures, and the extent of the responses stayed about the same along the exposure days. Sensory irritation was fairly minor. Pulmonary irritation was more pronounced during the latter part of the repeated exposures compared to the single exposures and the beginning of the repeated exposures. Sensory and pulmonary irritation were observed also in the control group, and, therefore, reaction by-products (NO(2) and C(3)H(6)) may have contributed to the irritation effects. TiO(2) NPs accumulated mainly in the pulmonary macrophages, and they did not cause nasal or pulmonary inflammation. In conclusion, the irritation and inflammation potencies of studied TiO(2) seemed to be low.
机译：纳米技术的使用呈指数级增长，而工程纳米颗粒（NPs）可能对健康产生的不利影响迄今仍鲜为人知。标准化的小鼠生物测定法用于研究感官和肺刺激，气流受限和纳米TiO（2）的炎症效力。一次暴露（0.5 h）到原位生成的TiO（2）（主要粒径为20 nm;分别在质量浓度为8、20和30 mg / m时的几何平均直径为91、113和130 nm（3）（3） ;结晶相锐钛矿+板钛矿（3：1））在每种研究的暴露浓度下均会导致导气管的气流受限，这表现为呼气流量的减少，为基线的最低73％。反应不是剂量依赖性的。以30 mg / m（3）的质量浓度重复暴露（总共16小时，1小时/天，4天/周，共4周）导致像单次暴露一样强烈的气流限制效果，以及程度在暴露天数中，几乎没有反应。感觉刺激很小。与单次暴露和重复暴露的开始相比，在重复暴露的后期，肺部刺激更为明显。在对照组中也观察到感觉和肺部刺激，因此，反应副产物（NO（2）和C（3）H（6））可能对刺激有贡献。 TiO（2）NPs主要在肺巨噬细胞中积累，它们不会引起鼻腔或肺部炎症。总之，研究的TiO（2）的刺激性和发炎能力似乎很低。

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