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首页> 外文期刊>Archives of Toxicology >Association of XRCC1 polymorphisms with arsenic methylation
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Association of XRCC1 polymorphisms with arsenic methylation

机译：XRCC1多态性与砷甲基化的关联

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摘要

The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMA(V)) and lower dimethylarsinic acid (DMA(V))/MMA(V) ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.
机译：X射线修复交叉互补组1中的四个单核苷酸多态性（p.Arg194Trp，p.Arg280His，p.Pro206Pro和p.Arg399Gln）与尿砷代谢物和8-羟基-2'-脱氧鸟苷（8 -OHdG）在越南人口中进行调查（n = 100）。 p.Pro206Pro中具有AA基因型的个体显示的尿单甲基ar酸（MMA（V））和二甲基ar子酸（DMA（V））/ MMA（V）的比率明显高于基因型AG。至于p.Arg399Gln，Arg / Arg纯合受试者和Arg / Gln杂合个体均比Gln / Gln纯合体显示出明显更高的尿无机As百分比和更低的8-OHdG浓度。我们的结果表明，Arg399Gln是一种功能性SNP，可能与DNA修复活性有关。

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