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首页> 外文期刊>Archives of microbiology >Insights into the mode of action of anticandidal herbal monoterpenoid geraniol reveal disruption of multiple MDR mechanisms and virulence attributes in Candida albicans
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Insights into the mode of action of anticandidal herbal monoterpenoid geraniol reveal disruption of multiple MDR mechanisms and virulence attributes in Candida albicans

机译：对抗候选草药单萜类香叶醇的作用方式的洞察揭示了白色念珠菌的多种MDR机制和毒力属性的破坏

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摘要

The anticandidal potential of Geraniol (Ger) against Candida albicans has already been established. The present study reveals deeper insights into the mechanisms of action of Ger. We observed that the repertoire of antifungal activity was not only limited to C. albicans and its clinical isolates but also against non-albicans species of Candida. The membrane tampering effect was visualized through transmission electron micrographs, depleted ergosterol levels and altered plasma membrane ATPase activity. Ger also affects cell wall as revealed by spot assays with cell wall-perturbing agents and scanning electron micrographs. Functional calcineurin pathway seems to be indispensable for the antifungal effect of Ger as calcineurin signaling mutant was hypersensitive to Ger while calcineurin overexpressing strain remained resistant. Ger also causes mitochondrial dysfunction, impaired iron homeostasis and genotoxicity. Furthermore, Ger inhibits both virulence attributes of hyphal morphogenesis and biofilm formation. Taken together, our results suggest that Ger is potential antifungal agent that warrants further investigation in clinical applications so that it could be competently employed in therapeutic strategies to treat Candida infections.
机译：香叶醇（Ger）对白色念珠菌的杀人潜力已经确定。本研究揭示了更深入的见解对Ger的作用机制。我们观察到，抗真菌活性的库不仅限于白色念珠菌及其临床分离株，而且还针对念珠菌的非白色念珠菌。通过透射电子显微照片，麦角固醇水平降低和质膜ATPase活性改变，可以看到膜的篡改效果。 Ger还影响细胞壁，如通过细胞壁干扰剂和扫描电子显微照片的斑点检测所揭示的。功能性钙调磷酸酶途径对于Ger的抗真菌作用似乎是必不可少的，因为钙调磷酸酶信号转导突变体对Ger过敏，而钙调磷酸酶过表达菌株仍然具有抗性。 Ger还引起线粒体功能障碍，铁稳态和遗传毒性受损。此外，Ger抑制菌丝形态发生和生物膜形成的毒力属性。综上所述，我们的结果表明，Ger是潜在的抗真菌剂，需要在临床应用中进行进一步研究，以便可以有效地用于治疗念珠菌感染的治疗策略中。

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