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首页> 外文期刊>Archives of Oral Biology >Tooth injury increases expression of the cold sensitive TRP channel TRPA1 in trigeminal neurons.
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Tooth injury increases expression of the cold sensitive TRP channel TRPA1 in trigeminal neurons.

机译：牙齿损伤会增加三叉神经元中冷敏TRP通道TRPA1的表达。

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OBJECTIVE: Transient receptor potential (TRP) channels, a family of structurally related proteins have been implicated in the sensation of pain and hyperalgesia caused by exogenous and endogenous agonists, as well as touch, pH, and temperature. The objective of this study was to determine the effects of tooth injury on the expression of the cold sensitive channel TRPA1, in the trigeminal ganglion, the primary source of sensory and nociceptive innervation of teeth. DESIGN: We analyzed TRPA1 expression in a rodent model of tooth injury, by Western blot analyses of proteins extracted from trigeminal ganglia. RESULTS: We found that TRPA1 was selectively increased in trigeminal ganglia innervating injured teeth when compared to TRPA1 expression in trigeminal ganglia innervating healthy teeth. CONCLUSIONS: Our results provide the first evidence of increased expression of a cold-sensitive TRP channel in trigeminal ganglia after pulp exposure, and are consistent with the possibility that increased expression and function of TRPA1 in trigeminal neurons contributes to hyperalgesia and allodynia following tooth injury.
机译：目的：瞬态受体电位（TRP）通道是结构相关蛋白家族，与外源性和内源性激动剂以及触摸，pH和温度引起的疼痛和痛觉过敏有关。这项研究的目的是确定牙齿损伤对三叉神经节中冷敏感通道TRPA1表达的影响，三叉神经节是牙齿感觉和伤害感受神经支配的主要来源。设计：我们通过对从三叉神经节提取的蛋白质进行蛋白质印迹分析，分析了啮齿动物啮齿动物模型中TRPA1的表达。结果：我们发现，与三叉神经节支配健康牙齿的TRPA1表达相比，三叉神经节支配损伤牙齿中的TRPA1选择性升高。结论：我们的结果提供了牙髓暴露后三叉神经节中冷敏TRP通道表达增加的第一个证据，并且与三叉神经元中TRPA1表达和功能增加导致牙齿损伤后痛觉过敏和异常性疼痛的可能性一致。

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