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首页> 外文期刊>Archives of Oral Biology >Comparative effectiveness of NiCl2, Ni- and NiO-NPs in controlling oral bacterial growth and biofilm formation on oral surfaces
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Comparative effectiveness of NiCl2, Ni- and NiO-NPs in controlling oral bacterial growth and biofilm formation on oral surfaces

机译：NiCl2，Ni-和NiO-NPs在控制口腔细菌生长和在口腔表面形成生物膜的比较有效性

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Objective Oral ailments are often treated with antibiotics, which are rendered ineffective as bacteria continue to develop resistance against them. It has been suggested that the nanoparticles (NPs) approach may provide a safer and viable alternative to traditional antibacterial agents. Therefore, nickel (Ni)- and nickel oxide (NiO)-NPs were synthesized, characterized and assessed for their efficacy in reducing oral bacterial load in vitro. Also, the effects of bulk compound NiCl2 (Ni ions), along with the Ni- and NiO-NPs on bacterial exopolysaccharide (EPS) production and biofilm formation on the surface of artificial teeth, and acrylic dentures, were investigated. Methods Total bacteria from a healthy male were collected and adjusted to 4 × 109 cells/ml for all the tests. Effect of the NPs on growth, biofilm formation, EPS production and acid production from glucose was tested using standard protocols. Results Data revealed that the Ni-NPs (average size 41.23 nm) exhibited an IC50 value of 73.37 μg/ml against total oral bacteria. While, NiO-NPs (average size 35.67 nm) were found less effective with much higher IC50 value of 197.18 μg/ml. Indeed, the Ni ions exhibited greater biocidal activity with an IC50 value of 70 μg/ml. Similar results were obtained with biofilm inhibition on the surfaces of dental prostheses. The results explicitly suggested the effectiveness of tested Ni compounds on the growth of oral bacteria and biofilm formation in the order as NiCl2 Ni-NPs NiO-NPs. Conclusion The results elucidated that Ni-NPs could serve as effective nanoantibiotics against oral bacteria.
机译：目的口腔疾病通常使用抗生素治疗，由于细菌继续对它们产生抵抗力，抗生素已无效。已经提出，纳米颗粒（NP）方法可以为传统抗菌剂提供更安全和可行的替代方法。因此，合成了镍（Ni）-和氧化镍（NiO）-NP，表征并评估了它们在体外减少口腔细菌负荷方面的功效。此外，还研究了散装化合物NiCl2（Ni离子）以及Ni-和NiO-NPs对细菌外多糖（EPS）的产生以及在人造牙齿和丙烯酸义齿上生物膜形成的影响。方法收集来自健康男性的细菌总数，并调整至4×109细胞/ ml。使用标准方案测试了NP对葡萄糖生长，生物膜形成，EPS产生和酸产生的影响。结果数据显示，Ni-NPs（平均粒径41.23 nm）对口腔细菌的IC50值为73.37μg/ ml。同时，发现NiO-NP（平均尺寸35.67 nm）效果不佳，IC50值更高，为197.18μg/ ml。实际上，Ni离子具有更强的杀菌活性，IC50值为70μg/ ml。在牙修复体表面抑制生物被膜也获得了类似的结果。结果明确表明，按照NiCl2> Ni-NPs> NiO-NPs的顺序，测试的Ni化​​合物对口腔细菌生长和生物膜形成的有效性。结论研究结果表明，镍纳米粒可作为有效的纳米抗菌剂对口腔细菌。

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